[Retracted] Isovitexin Suppresses Stemness of Lung Cancer Stem-Like Cells through Blockage of MnSOD/CaMKII/AMPK Signaling and Glycolysis Inhibition

Figure 4

Isovitexin inhibited stemness and glycolysis of LCSLCs. The LCSLCs were treated with isovitexin (0, 5, 10, 20 μg/mL). Isovitexin inhibited the sphere-forming (a), colony-forming (b), migratory (c), and invasive (d) ability of LCSLCs in a concentration-dependent manner. Isovitexin reduced the expression of CD133, CD44, and ALDH1 (e); Nanog and Bmi1 (f); and MnSOD, p-AMPK, and p-CaMkII of LCSLCs in a concentration-dependent manner and did not exert apparent effects on the expression of CaMkII and AMPK (g). (h) Isovitexin suppressed the glycolysis in LCSLCs in a concentration-dependent manner. vs. control; ^# vs. 5 μg/mL isovitexin treatment ().

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