[Retracted] Isovitexin Suppresses Stemness of Lung Cancer Stem-Like Cells through Blockage of MnSOD/CaMKII/AMPK Signaling and Glycolysis Inhibition

Figure 6

The overexpression of MnSOD attenuated isovitexin-induced inhibition of stemness and glycolysis of LCSLCs. The LCSLCs were firstly infected with recombinant lentivirus packaging MnSOD cDNA (Lent-MnSOD) or GFP (Lent-GFP) and then treated with isovitexin (0, 10 μg/mL) as indicated. Lent-MnSOD attenuated isovitexin inhibition of the sphere-forming (a), colony-forming (b), migratory (c), and invasive (d) ability of LCSLCs. Lent-MnSOD weakened isovitexin downregulation of CD133, CD44, and ALDH1 (e); Nanog and Bmi1 (f); and MnSOD, p-AMPK, and p-CaMkII (g) in LCSLCs. (h) Lent-MnSOD decreased isovitexin reduction of the glycolysis in LCSLCs. vs. Lent-GFP; ^# vs. 10 μg/mL isovitexin treatment ().

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