[Retracted] Isovitexin Suppresses Stemness of Lung Cancer Stem-Like Cells through Blockage of MnSOD/CaMKII/AMPK Signaling and Glycolysis Inhibition

Figure 7

Effects of isovitexin on growth of LCSLCs in vivo. (A1) The 2nd-generation sphere-forming cells (SFCs) derived from H460 cells were injected in the left flank of Balb/c-nu mice, and parental H460 cells (PCs) were injected in the right flank. Tumorigenicity of SFCs was stronger than PCs. (A2) The histological patterns of tumor tissues stained with hematoxylin and eosin (H&E). (B1) MnSOD shRNA inhibited the growth of LCSLCs in vivo; however, MnSOD cDNA increased its proliferation in vivo. (B2) MnSOD protein (marked as yellow) was knocked down or overexpressed in tumor tissues from LCSLCs by MnSOD shRNA or MnSOD cDNA in vivo. Isovitexin inhibited tumor growth of LCSLCs (C1) and MnSOD expression (C2) in vivo, in a concentration-dependent manner.

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