The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NF-<i>κ</i>B Pathway in Created Temporomandibular Osteoarthritis

<div>Effect of RES on IL-1<i>β</i>-induced apoptosis in the chondrocytes. (a) The optimum dose of RES was determined by MTT after cotreatment for 12 h. (b, c) Flow cytometric analysis for chondrocyte apoptosis. RES treatment could decrease cell apoptosis. (d) The mRNA expression of COX-2 and P65 in each group; RES treatment could suppress COX-2 and P65 expression in vitro. (e) The mRNA expression of MMP1 and MMP13 in each group. (f) The levels of cartilage markers’ (ACAN, COL2) gene expressions in chondrocytes were determined by RT-PCR. 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BioMed Research International

fig2

Figure 2

Figure 2: The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NF-<i>κ</i>B Pathway in Created Temporomandibular Osteoarthritis 

Figure 2 | The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NF-κB Pathway in Created Temporomandibular Osteoarthritis 