BioMed Research International / 2021 / Article / Tab 2 / Research Article
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 (TMPRSS2 ) and SARS-CoV-2 Table 2 Prediction of effect of missense variants on phylogenetic conservation, phenotypic analysis, and posttranslational modification sites in human TMPRSS2 protein.
SNP ID Variant Posttranslational modifications (PTMs) by ModPred Phylogenetic conservation Predicted effect by MutPred rs12329760 V160M — 6, B — rs781089181 G181R — 9, B Loss of loop Altered transmembrane protein Gain of helix Loss of disulfide linkage at C185 Gain of ADP-ribosylation at G181 rs762108701 R240C Proteolytic cleavage 5, E — ADP-ribosylation rs1185182900 P335L Proteolytic cleavage 3, E — rs570454392 G432A Proteolytic cleavage 9, E, F Loss of relative solvent accessibility Loss of loop Altered transmembrane protein Altered metal binding Gain of disulfide linkage at C437 Gain of catalytic site at D435 Gain of pyrrolidone carboxylic acid at Q431 rs867186402 D435Y Proteolytic cleavage 9, E, F Altered transmembrane protein Altered ordered interface Altered metal binding Loss of relative solvent accessibility Loss of catalytic site at G439 Gain of disulfide linkage at C437 Gain of pyrrolidone carboxylic acid at Q43 Gain of sulfation at D435
