Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 (TMPRSS2) and SARS-CoV-2

Table 7

TMPRSS2 structure validation using Verify3D and PROCHECK servers.

	Verify3D	PROCHECK
	% of amino acid in the 3D/1D profile	Favored region	Allowed region	Disallowed region
Native	93.02	86.9% (258)	12.8% (38)	0.3% (1)
V160M	97.09	88.9% (264)	10.1% (30)	1.0% (3)
G181R	93.02	89.3% (266)	10% (30)	0.7% (2)
R240C	96.80	89.9% (267)	9.4% (28)	0.7% (2)
P335L	95.64	90.6% (270)	8.7% (26)	0.7% (2)
G432A	99.42	88.6% (264)	10.7% (31)	0.7% (2)
D435Y	94.19	87.2% (259)	11.8% (35)	1.0% (3)