Prognostic Value of Immune-Inflammatory Index in PSI IV-V Patients with COVID-19

Table 2

Sensitivity, specificity, positive predictive value, and negative predictive value of each immune-inflammatory index parameter for COVID-19 mortality prediction.

Immune-inflammatory index parameter	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)	Area under the ROC curve (95% CI)
Neutrophils (/L)					0.67 (0.44–0.89)
1st tertile	100 (67.6–100)	31.6 (15.4–54.0)	38.1 (20.8–59.1)	100 (70.0–100)
2nd tertile	87.5 (52.9–99.4)	63.2 (41.0–80.8)	50.0 (26.8–73.2)	92.3 (66.7–99.6)
3rd tertile	37.5 (13.7–69.4)	79.0 (56.7–91.5)	42.9 (15.8–75.0)	75.0 (53.1–88.8)
Lymphocytes (/L)					0.68 (0.47–0.90)
1st tertile	55.6 (26.7–81.1)	15.8 (5.5–37.6)	23.8 (10.6–45.1)	42.9 (15.8–75.0)
2nd tertile	44.4 (18.9–73.3)	47.4 (27.3–68.3)	28.6 (11.7–54.7)	64.3 (38.8–83.7)
3rd tertile	0 (0–29.9)	68.4 (46.0–84.6)	0 (0–39.0)	59.1 (38.7–76.7)
NLR					0.75 (0.56–0.95)
1st tertile	88.9 (56.5–99.4)	31.6 (15.4–54.0)	38.1 (20.8–59.1)	85.7 (48.7–99.3)
2nd tertile	77.8 (45.3–96.1)	63.2 (41.0–80.9)	50.0 (26.8–73.2)	85.7 (60.1–97.5)
3rd tertile	44.4 (18.9–73.3)	84.2 (62.4–94.5)	57.1 (25.1–84.2)	76.2 (54.9–89.4)
PCT (ng/mL)					0.78 (0.60–0.96)
1st tertile	100 (67.6–100)	36.8 (19.2–59.0)	40.0 (21.9–61.3)	100 (64.6–100)
2nd tertile	75.0 (40.9–95.6)	68.4 (46.0–84.6)	50.0 (25.4–74.6)	86.7 (62.1–97.6)
3rd tertile	37.5 (13.7–69.4)	89.5 (68.6–98.1)	60.0 (23.1–92.9)	77.3 (56.6–89.9)

CI: confidence interval; NLR: neutrophil-to-lymphocyte ratio; NPV: negative predictive value; PCT: procalcitonin; PPV: positive predictive value; ROC: receiver operator characteristic.