Antidepressant Active Components of Bupleurum chinense DC-Paeonia lactiflora Pall Herb Pair: Pharmacological Mechanisms

Table 3

Active compounds in Bupleurum chinense DC-Paeonia lactiflora Pall herb pair regulate monoamine neurotransmitters.

Compound	Model	Animal species	Dosage	Behaviour involved	Mechanism of action/main indicators	References
Saikosaponin A	CUMS	Male SD rat	50 mg/kg	OFT and SPT	Weight↑, hippocampus DA↑, and hippocampus PRRT2↑	[52]
Quercetin	CUMS	Male Swiss albino mice	25 mg/kg	MFST, TST, and OFT	Brain5-HT↑, brain glutamate, IL-6, TNF-α↓, and relieving brain oxidative stress	[53]
	Restraint stress	Male Albaino wistar mice	20 mg/kg/ml	FST, LDA, EPM, and MWM	Prevent oxidase damage, regulate 5-HT, and cholinergic	[54]
Gallic acid	iAS	SD male rat	50, 100 mg/kg	EPM, LDA, FST, and MWM	Relieve brain oxidative stress and brain AChE↓	[56]
Protocatechuic acid	OB	Male Wistar rat	100, 200 mg/kg	FST and OFT	Hippocampus 5-HT, norepinephrine, DA↑, hippocampus BNDF↑, hippocampus TNF-α, IL-6, CORT, and hippocampus oxidase damage↓	[58]

Note: LDA: Light-dark activity box; iAS: Arsenic; OB: olfactory bulbectomy; MWM: Morris water maze; FST: forced swimming test; EPM: Elevated Plus Maze; OFT: open field test; 5-HT: serotonin; CORT: cortisol; IL-6: interleukin-6; TNF-α: Tumor necrosis factor-α; AChE: acetylcholinesterase; DA: dopamine; BDNF: brain-derived neurotrophic factor; MFST: Modified Forced Swim Test; OB: olfactory bulbectomy; TST: tail suspension test; CUMS: chronic unpredictable mild stress.