Updates on Quantitative MRI of Diffuse Liver Disease: A Narrative Review

Table 1

Magnetic resonance imaging studies on diffusion-weighted imaging for diffuse liver disease.

Study	patients	Objective	Model performance	Reference standard	Nature of study
Guiu et al.,; Radiol. [50]	108	, , and values derived from IVIM in steatosic livers vs. normal livers		Clinical assessment of type 2 diabetes	Monocentric; Prospective
Murphy et al., J Magnetic Resonance Imaging [51]	89	Associations between histologic alterations and DWI in NAFLD		Liver biopsy	Monocentric; Prospective observational
Lewin et al.,; Hepatology [52]	74	DWI in predicting fibrosis or cirrhosis vs. healthy volunteers		Liver biopsy	Monocentric; Prospective
Taouli et al.,; AJR American Journal of Roentgenology [53]	30	ADC in quantification of liver fibrosis at different stages		Liver biopsy	Monocentric; Prospective
Yoon et al.,; Journal of Computer Assisted Tomography[54]	55	IVIM parameters (, , and ) vs. ADC in hepatic fibrosis (F0-1 vs. F4)		Liver biopsy	Monocentric; Retrospective
Akpinar et al.,; Journal of Medical Imaging and Radiation Oncology [56]	55	ADC to assess iron overload in β-thalassemia major patients vs. iron overload MRI sequences		Laboratory blood test for β-thalassemia major diagnosis	Monocentric; Retrospective
Kovač et al.,; Acta Radiologica[58]	108	ADC in primary sclerosing cholangitis		MRI	Monocentric; Prospective

D: diffusion coefficient; D: pseudodiffusion coefficient; f: microperfusional fraction; DWI: diffusion-weighted imaging; NAFLD: nonalcoholic fatty liver disease; ADC: apparent diffusion coefficient; AUC: area under the curve; IVIM: intravoxel incoherent motion.