Comparison of Biochemical Parameters between Mouse Model and Human after Paraquat Poisoning

Table 2

ROC curve analysis.

Variable	Area under ROC curve	95% CI	Cutoff point	Sensitivity (%)	Specificity (%)	Youden index (%)
Age	0.779	0.597-0.961	>48.00	90	68.40	58.40
Ingested volume	0.953	0.875-1.00	>75.00	80	100	80
Urinary PQ concentration	0.883	0.749-1.00	>82.50	80	86.70	66.70
AST	0.832	0.677-0.986	>24.50	80	78.95	58.95
ALT	0.845	0.700-0.990	>44.50	60	94.74	54.74
BUN	0.797	0.619-0.976	>7.17	60	94.70	54.70
K^+	0.761	0.553-0.968	<3.72	80	68.40	48.40
Cl^-	0.763	0.558-0.969	<103.00	60	89.50	49.50
Amylase	0.889	0.726-1.00	>136.00	66.67	100	66.67
NLR	0.737	0.504-0.970	>15.00	70	94.70	64.70

Abbreviations: ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; CI: confidence interval; Cl^-: serum chlorine; K⁺: serum potassium; NLR: neutrophil-to-lymphocyte ratio; PQ: paraquat; ROC, receiver operating characteristic.