BioMed Research International

Research Article

Aldehyde Dehydrogenase 2 Family Member (ALDH2) Is a Therapeutic Index for Oxaliplatin Response on Colorectal Cancer Therapy with Dysfunction p53

Table 1

Hub genes in the upregulated or downregulated PPI network.
Gene IDGene nameDegree
Hub genes in the upregulated PPI network
SPRR1BSmall proline-rich protein 1B3.0
SPRR1ASmall proline-rich protein 1A2.0
SPRR3Small proline-rich protein 32.0
COL8A1Collagen type VIII alpha 12.0
LEPREL2Prolyl 3-hydroxylase 22.0
COL9A3Collagen type IX alpha 32.0
CSAG1Chondrosarcoma-associated gene 12.0
Hub genes in the downregulated PPI network
AKR1B1Aldo-keto reductase family 1 member B1 (aldose reductase)5.0
AKR1B10Aldo-keto reductase family 1 member B10 (aldose reductase)5.0
AKR1C3Aldo-keto reductase family 1 member C3, EC 1.3.0
HKDC1Hexokinase domain-containing protein 13.0
COL27A1Collagen type XXVII alpha 1 chain3.0
ALDH2Aldehyde dehydrogenase, mitochondrial, EC 1.2.1.32.0
MGLLMonoacylglycerol lipase2.0
FGFR3Fibroblast growth factor receptor 32.0
FGF9Fibroblast growth factor 92.0
FGFR2Fibroblast growth factor receptor 22.0
TFF1Trefoil factor 12.0
F5Coagulation factor 52.0
CFTRCystic fibrosis transmembrane conductance regulator2.0