Research Article
Aldehyde Dehydrogenase 2 Family Member (ALDH2) Is a Therapeutic Index for Oxaliplatin Response on Colorectal Cancer Therapy with Dysfunction p53
Table 1
Hub genes in the upregulated or downregulated PPI network.
| Gene ID | Gene name | Degree |
| Hub genes in the upregulated PPI network | SPRR1B | Small proline-rich protein 1B | 3.0 | SPRR1A | Small proline-rich protein 1A | 2.0 | SPRR3 | Small proline-rich protein 3 | 2.0 | COL8A1 | Collagen type VIII alpha 1 | 2.0 | LEPREL2 | Prolyl 3-hydroxylase 2 | 2.0 | COL9A3 | Collagen type IX alpha 3 | 2.0 | CSAG1 | Chondrosarcoma-associated gene 1 | 2.0 | Hub genes in the downregulated PPI network | AKR1B1 | Aldo-keto reductase family 1 member B1 (aldose reductase) | 5.0 | AKR1B10 | Aldo-keto reductase family 1 member B10 (aldose reductase) | 5.0 | AKR1C3 | Aldo-keto reductase family 1 member C3, EC 1. | 3.0 | HKDC1 | Hexokinase domain-containing protein 1 | 3.0 | COL27A1 | Collagen type XXVII alpha 1 chain | 3.0 | ALDH2 | Aldehyde dehydrogenase, mitochondrial, EC 1.2.1.3 | 2.0 | MGLL | Monoacylglycerol lipase | 2.0 | FGFR3 | Fibroblast growth factor receptor 3 | 2.0 | FGF9 | Fibroblast growth factor 9 | 2.0 | FGFR2 | Fibroblast growth factor receptor 2 | 2.0 | TFF1 | Trefoil factor 1 | 2.0 | F5 | Coagulation factor 5 | 2.0 | CFTR | Cystic fibrosis transmembrane conductance regulator | 2.0 |
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