Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective

Table 1

Some recent curcumin nanoformulations and beneficial effects on diabetic complications.

Type of nanoformulations	Method	Encapsulation efficiency (%)	Size (nm)	Beneficial effects	References
Curcumin nanoparticles loaded in Tween 60	Solvent evaporation nanoprecipitation	93	40-50	↓ Endothelial dysfunction	[103]
Curcumin-loaded liposomes coated with PEG	Film hydration	80	140	Anti-inflammatory	[54]
Curcumin-ZnO complex loaded with chitosan	Solvent evaporation followed by ion gelation	Not reported	43	↓ Blood glucose level maintain normal lipid profile; ↑ Solubility of curcumin; ↑ Antioxidant activity	[72]
Curcumin-loaded PLGA nanoparticles	Emulsion-diffusion-evaporation	66	237	Protective effect on inflammatory markers improve lipid metabolisms	[76]
Curcumin-loaded Pluronic nanomicelles	Nanoprecipitation	88-91	333	↑ β-Cell regeneration	[101]
Curcumin-loaded PLA-PEG nanoparticles	Emulsion-diffusion-evaporation	98	117	Protective effect on liver inflammation	[73]
Curcumin-loaded PLGA nanoparticles	Emulsion-diffusion-evaporation	56	282	Delaying diabetic cataracts	[77]
Curcumin-loaded nanoparticles coated with chitosan	Ion crosslinking	77	91	↑ Healing of diabetic wounds	[107]
Curcumin nanoparticles within QPAMAM (G3)	Emulsion solvent evaporation	Not reported	40	Preventing oxidant mediated diabetic cataract development	[108]
Curcumin-encapsulated PBLG-PEG-PBLG nanocapsules	Ring-opening polymerization	32	30	↓ Diabetic cardiomyopathy	[109]

Abbreviations and symbols: ↑: increase; ↓: decrease; PLA: polylactic acid; PEG: polyethylene glycol; PBLG: poly(gamma-benzyl l-glutamate); QPAMAM (G3): quaternary ammonium poly(amidoamine) dendrimer.