Analgesic, Anti-inflammatory, Antipyretic, and In Silico Measurements of Sonneratia caseolaris (L.) Fruits from Sundarbans, Bangladesh

Table 7

Binding characteristics of ligands against mu (μ) opioid receptor.

Ligands	Protein	Binding affinity (kcal/mol)	Interacting amino acids
Tramadol	5C1M	–6.4	His54, Gln124, Met151, Tyr326, Trp293, Asp147, Tyr148, Ile296, Val236, Val300
Vanillic acid		–5.4	Val300, Ile296, Val236, His297, Trp293, Ile322, Tyr326, Asp147, Met151, Val236
Oleanolic acid		–6.4	Ile146, Trp192, Leu116, Tyr149, Leu112, Asn109, Thr153, Asn150
Maslinic acid		–6.7	Asn150, Tyr149, Trp192, Asn109, Phe108, Leu112, Leu116, Lle146
Luteolin		–7.9	Leu232, Lys233, Val300, Val236, Tyr148, Asp147, Ile322, Tyr326, Gln124, Ile296, His297
Myricetin		–7.6	His297, Ile296, Glu124, Ile322, His54, Ile144, Asp147, Tyr148, Val236, Val300
Ellagic acid		–8.6	His297, Val300, Ile296, Tyr148, His54, Asp147, Gln124, Tyr326

Compounds marked bold showed the best binding affinities.