[Retracted] KDOAM-25 Overcomes Resistance to MEK Inhibitors by Targeting KDM5B in Uveal Melanoma

<div>KDOAM-25 directly binds to KDM5B. (a) DARTS analysis of recombinant human KDM5B proteins shows that differential pronase-mediated proteolysis after KDOAM-25 (50 <i>μ</i>M) addition is apparent for KDM5B, detected by SDS-PAGE and blotting with an <i>α</i>-KDM5B monoclonal antibody. (b) Quantitative analysis of <i>α</i>-KDM5B in (A). (C) MST analysis determined the Kd of KDOAM-25 towards His-KDM5B (487.75 nm) labeled with RED-tris-NTA 2nd Generation dye. Concentration is reported in nanomolar.</div>

BioMed Research International

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Figure 4

Figure 4: [Retracted] KDOAM-25 Overcomes Resistance to MEK Inhibitors by Targeting KDM5B in Uveal Melanoma 