Repression of the Antioxidant Pyrroloquinoline Quinone in Skin Aging Induced by Bmi-1 Deficiency

<div>The expression of Bmi-1 in the skin. (a) qRT-PCR analysis of mRNA levels for Bmi-1 expression in organ extracts from 8-week-old mice. The expression level is calculated as a ratio to GAPDH, expressed relative to the liver. (b) Representative RT-PCR of skin extracts showing expression of Bmi-1; GAPDH was the loading control. (c) Bmi-1 mRNA relative levels detected by qRT-PCR, calculated as a ratio to GAPDH, expressed relative to WT. (d) Immunohistochemical analysis for expression of Bmi-1 in the skin from 1 m-, 9 m-, and 18 m-old mice. (e) The positive cell percentages of Bmi-1 were determined by image analysis. 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BioMed Research International

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Figure 1

Figure 1: Repression of the Antioxidant Pyrroloquinoline Quinone in Skin Aging Induced by Bmi-1 Deficiency 