Potential Factors Predicting Histopathologically Upgrade Discrepancies between Endoscopic Forceps Biopsy of the Colorectal Low-Grade Intraepithelial Neoplasia and Endoscopic Resection Specimens

Table 3

Multivariate analyses for predictive factors demonstrating histopathologically upgrade discrepancies between pretreatment EFB and endoscopic resection specimens.

Characteristics	Univariate analysis		Multivariable analysis
	OR (95% CI)	value	OR (95% CI)	value
Female	1.39 (0.98,1.97)	0.061		0.054
	1.18 (0.84, 1.66)	0.337		0.256
Past medical history
NSAID	3.94 (2.20, 7.06)	<0.001	4.83 (2.27, 10.27)	<0.001
Colorectal polyps	0.86 (0.33,2.27)	0.760
FAP	2.34 (0.21,25.98)	0.488
CRC	0.77 (0.36,1.65)	0.497
Lack of standardization of EFB number	4.22 (2.96, 6.03)	<0.001	2.99 (1.91, 4.68)	<0.001
≥25% villous in EFB diagnosis	2.04 (1.33, 3.13)	0.001		0.845
Maximum  cm	10.81 (2.64, 44.36)	0.001	6.18 (1.32, 28.99)	0.021
Lobulated shape	6.70 (4.63, 9.69)	<0.001	2.68 (1.65, 4.36)	<0.001
Erythema	4.59 (3.07, 6.85)	<0.001	2.42 (1.50, 3.91)	<0.001
Erosion	16.26 (10.18, 25.95)	<0.001	7.12 (3.91, 12.94)	<0.001
Surface unevenness	9.71 (6.54, 14.42)	<0.001	2.31 (1.33, 4.01)	0.003
LST	0.62 (0.24, 1.60)	0.322
Multiple colorectal polyps	1.30 (0.92, 1.83)	0.138
Distal location of the target adenoma	2.32 (1.40, 3.85)	<0.001	3.29 (1.68, 6.41)	<0.001