Diagnostic Performance of Transient Elastography Versus Two-Dimensional Shear Wave Elastography for Liver Fibrosis in Chronic Viral Hepatitis: Direct Comparison and a Meta-Analysis

Table 4

Meta-analysis of studies with head-to-head comparison of TE and 2D-SWE in staging fibrosis.

Methods	No. of studies (no. of patients)	Cutoff values range	Sensitivity (95% CI)	Specificity (95% CI)	PLR (95% CI)	NLR (95% CI)	AUROC(95% CI)	DOR (95% CI)
Staging fibrosis stage
TE	8 (1301)	6.1-11.8	0.78 (0.72-0.84)	0.79 (0.71-0.86)	3.71 (2.43-5.67)	0.28 (0.21-0.38)	0.85 (0.82-0.88)	14.12 (7.88-25.31)
2D-SWE	8 (1301)	6-9.58	0.84 (0.78-0.88)	0.84 (0.77-0.88)	4.87 (3.22-7.36)	0.2 (0.13-0.32)	0.90 (0.88-0.93)	25.19 (11.47-55.32)
Staging fibrosis stage
TE	6 (1089)	8-8.6	0.85 (0.81-0.89)	0.88 (0.81-0.93)	7.05 (4.04-12.32)	0.17 (0.12-0.24)	0.91 (0.88-0.93)	44.23 (20.5-95.43)
2D-SWE	6 (1089)	7-9.1	0.88 (0.82-0.92)	0.85 (0.77-0.91)	6.19 (371-10.30)	0.14 (0.08-0.23)	0.93 (0.90-0.95)	50.24 (21.09-119.69)
Staging fibrosis stage
TE	6 (1089)	11.2-14.6	0.90 (0.83-0.94)	0.91 (0.84-0.95)	10.7 (5.46-20.99)	0.11 (0.05-0.24)	0.95 (0.93-0.97)	110.24 (40.75-298.24)
2D-SWE	6 (1089)	9.7-11.3	0.95 (0.85-0.99)	0.91 (0.86-0.95)	9.34 (5.91-14.76)	0.07 (0.02-0.27)	0.97 (0.95-0.98)	155.43 (63-383.43)

2D-SWE: two-dimensional shear wave elastography; AUROC: area under summary receiver operating characteristic; CI: confidence interval; DOR: diagnostic odds ratio; NLR: negative likelihood ratio; PLR: positive likelihood ratio; TE: transient elastography.