GO Description Count Log Hits hsa04151 PI3K-Akt signaling pathway 35 -38.739 AKT1, CCND1, BCL2, BCL2L1, CASP9, CDK2, CDK4, CDKN1A, CHUK, COL1A1, EGF, EGFR, ERBB2, ERBB3, GSK3B, HSP90AA1, IGF2, IKBKB, IL2, IL4, IL6, MCL1, MDM2, MET, MYC, NOS3, PIK3CG, MAPK1, MAPK3, PTEN, RAF1, RELA, SPP1, TP53, and VEGFA hsa05205 Proteoglycans in cancer 29 -36.389 AKT1, CCND1, CASP3, CAV1, CD44, CDKN1A, COL1A1, MAPK14, CTNNB1, EGFR, ERBB2, ERBB3, ESR1, HIF1A, IGF2, MDM2, MET, MMP2, MMP9, MYC, PLAU, PRKACA, MAPK1, MAPK3, RAF1, TNF, TP53, VEGFA, and HPSE hsa05215 Prostate cancer 28 -44.178 AKT1, AR, CCND1, BCL2, CASP9, CDK2, CDKN1A, CHUK, CTNNB1, E2F1, EGF, EGFR, ERBB2, GSK3B, HSP90AA1, IKBKB, MDM2, MMP3, MMP9, NFKBIA, PLAU, MAPK1, MAPK3, PTEN, RAF1, RB1, RELA, and TP53 hsa04010 MAPK signaling pathway 28 -30.404 AKT1, CASP3, CHUK, MAPK14, EGF, EGFR, ERBB2, ERBB3, FOS, HSPB1, IGF2, IKBKB, IL1A, IL1B, JUN, MET, MYC, PPP3CA, PRKACA, MAPK1, MAPK3, MAPK8, RAF1, RASA1, RELA, TNF, TP53, and VEGFA hsa04657 IL-17 signaling pathway 25 -38.472 CASP3, CASP8, CHUK, MAPK14, FOS, GSK3B, HSP90AA1, IFNG, IKBKB, IL1B, IL4, IL6, CXCL8, JUN, MMP1, MMP3, MMP9, NFKBIA, MAPK1, MAPK3, MAPK8, PTGS2, RELA, CCL2, and TNF hsa04218 Cellular senescence 25 -32.725 AKT1, CCND1, CCNA2, CDK1, CDK2, CDK4, CDKN1A, MAPK14, E2F1, IGFBP3, IL1A, IL6, CXCL8, MDM2, MYC, SERPINE1, PPP3CA, MAPK1, MAPK3, PTEN, RAF1, RB1, RELA, TP53, and CHEK2 hsa05206 MicroRNAs in cancer 25 -25.295 CCND1, BCL2, CASP3, CD44, CDKN1A, E2F1, EGFR, ERBB2, ERBB3, HMOX1, IKBKB, MCL1, MDM2, MET, MMP9, ABCC1, MYC, PLAU, MAPK1, MAPK3, PTEN, PTGS2, RAF1, TP53, and VEGFA hsa04668 TNF signaling pathway 23 -32.674 AKT1, CASP3, CASP8, CHUK, MAPK14, FOS, ICAM1, IKBKB, IL1B, IL6, JUN, MMP3, MMP9, NFKBIA, MAPK1, MAPK3, MAPK8, PTGS2, RELA, CCL2, SELE, TNF, and VCAM1 hsa05224 Breast cancer 23 -29.847 AKT1, BAX, CCND1, CDK4, CDKN1A, CTNNB1, E2F1, EGF, EGFR, ERBB2, ESR1, ESR2, FOS, GSK3B, JUN, MYC, PGR, MAPK1, MAPK3, PTEN, RAF1, RB1, and TP53 hsa04210 Apoptosis 22 -28.889 AKT1, BIRC5, BAX, BCL2, BCL2L1, CASP3, CASP8, CASP9, CHUK, CTSD, FOS, IKBKB, JUN, MCL1, NFKBIA, MAPK1, MAPK3, MAPK8, RAF1, RELA, TNF, and TP53 hsa04625 C-Type lectin receptor signaling pathway 21 -29.677 AKT1, CASP8, CHUK, MAPK14, IKBKB, IL1B, IL2, IL6, IL10, JUN, MDM2, NFKBIA, PPP3CA, MAPK1, MAPK3, MAPK8, PTGS2, RAF1, RELA, STAT1, and TNF hsa04660 T cell receptor signaling pathway 21 -29.677 AKT1, CD40LG, CDK4, CHUK, MAPK14, FOS, GSK3B, IFNG, IKBKB, IL2, IL4, IL10, JUN, NFKBIA, PPP3CA, MAPK1, MAPK3, MAPK8, RAF1, RELA, and TNF hsa05222 Small-cell lung cancer 21 -30.829 AKT1, BAX, CCND1, BCL2, BCL2L1, CASP3, CASP9, CDK2, CDK4, CDKN1A, CHUK, E2F1, IKBKB, MYC, NFKBIA, NOS2, PTEN, PTGS2, RB1, RELA, and TP53 hsa05208 Chemical carcinogenesis—reactive oxygen species 20 -21.114 AKT1, CHUK, MAPK14, EGF, EGFR, FOS, HIF1A, HMOX1, IKBKB, JUN, MET, NFKBIA, MAPK1, MAPK3, MAPK8, PTEN, RAF1, RELA, SOD1, and VEGFA hsa04659 Th17 cell differentiation 19 -25.608 CHUK, MAPK14, FOS, HIF1A, HSP90AA1, IFNG, IKBKB, IL1B, IL2, IL4, IL6, JUN, NFKBIA, PPP3CA, MAPK1, MAPK3, MAPK8, RELA, and STAT1 hsa04621 NOD-like receptor signaling pathway 19 -21.190 BCL2, BCL2L1, CASP8, CHUK, MAPK14, HSP90AA1, IKBKB, IL1B, IL6, CXCL8, JUN, NFKBIA, MAPK1, MAPK3, MAPK8, RELA, CCL2, STAT1, and TNF hsa04620 Toll-like receptor signaling pathway 18 -24.128 AKT1, CASP8, CHUK, MAPK14, FOS, IKBKB, IL1B, IL6, CXCL8, JUN, NFKBIA, MAPK1, MAPK3, MAPK8, RELA, SPP1, STAT1, and TNF hsa04380 Osteoclast differentiation 18 -22.496 AKT1, CHUK, MAPK14, FOS, IFNG, IKBKB, IL1A, IL1B, JUN, NFKBIA, PPARG, PPP3CA, MAPK1, MAPK3, MAPK8, RELA, STAT1, and TNF hsa05202 Transcriptional misregulation in cancer 18 -19.335 BAX, BCL2L1, RUNX2, CCNA2, CDKN1A, IGFBP3, IL6, CXCL8, MDM2, MET, MMP3, MMP9, MPO, MYC, PLAU, PPARG, RELA, and TP53 hsa04115 p53 signaling pathway 17 -25.120 BAX, CCND1, BCL2, BCL2L1, CASP3, CASP8, CASP9, CDK1, CDK2, CDK4, CDKN1A, IGFBP3, MDM2, SERPINE1, PTEN, TP53, and CHEK2
