The Regulatory Effects of MicroRNAs on Tumor Immunity

Table 2

Cell types and corresponding functions in the main miRNA interactions.

miRNA	Cell types	Functions	References
miR-21	Macrophages	Changes in the polarity of macrophages	[11]
miR-125a	HSCs	Regulates the survival of HSCs	[15]
miR-126	HSCs	Inhibits the cell cycle	[16]
miR-127	Macrophages	Changes in the polarity of macrophages	[13]
miR-124	Macrophages	Promotes the differentiation of M1 macrophages	[14]
miR-152	NK cell	Upregulates the activity of NK cells	[8]
miR-29	NK cell	Regulates NK cells indirectly through B7-H3	[19]
miR-142	DC	Enhances the activation of inflammatory factors	[22]
miR-155	DC	Suppresses DC-mediated immune response	[23]
miR-28	T cell	3-UTR binds directly to PD-1	[32]
miR-195	T cell	Regulates CD+4 T cell activation by CCDC88C	[34]
miR-448	T cell	Inhibits IDO1	[36]
miR-181a	T cell	Control TCR signal	[38]
miR-126	T cell	Acts on IRS-1, regulates T cell activation	[39]
miR-150	B cell	Acts on BCR, controls B cell differentiation	[40]
miR-1	CAF	Regulates FOXO3a/VEGF/CCL2	[45]
miR-206	CAF	Regulates FOXO3a/VEGF/CCL2	[45]
miR-31	CAF	Regulates FOXO3a/VEGF/CCL2	[45]
miR-186	NK cell	Suppresses immune escape	[59]
miR-142-5p	T cell	Overexpression inhibits the PD-1/PD-L1 pathway	[107]
miR-21	MDSC	Activates MDSC amplification	[57]
miR-138	T cell	Inhibits the expression of CTLA-4 and PD-1	[67]
miR-374b	T cell	Downregulates PD-1	[68]
miR-155	T cell	Inhibits PD-1 and CTLA-4	[71]
miR-1207-5p	CHO cell	Binding to B7-H4 3-UTR allele	[77]
miR-24	CHO cell	Associated with B7-H2	[87]
miR-172-92	CAR-T cell	Enhances CAR-T cell antigenicity	[96]
miR-153	CAR-T cell	Inhibits IDO1, enhances cell lethality	[104]