Potential Small Molecules for Therapy of Lupus Nephritis Based on Genetic Effect and Immune Infiltration

Table 2

Immune signatures of 9 potential small molecules and 7 common effective drugs.

	Small molecules	Inhibited cells
	Acetohexamide	Bn, DC, macrophage, monocyte, PBMC, Pre-B2 cell, Th, Tn
	Suloctidil	Bm, Bn, DC, PBMC, Th1, Tm, Tn, Treg
	Prenylamine	DC, macrophage, CTL, PBMC, Th1, Tm, Treg
Potential small molecules	Terfenadine	Bn, DC, Th1, Th2, Tm, Treg
	Prochlorperazine	B1 cell, Bm, Bn, DC, macrophage, PBMC, Th1, Th2, Tm, Treg
	Propofol	Bn, DC, monocyte, PBMC, Tm
	Benfluorex	Macrophage, PBMC, Tn, Tm
	Mefloquine	Bm, Bn, DC, PBMC, Th1, Treg
	Triprolidine	B1 cell, Bn, DC, macrophage, PBMC, Pre-B1 cell, CTL, Th1, Th17, Tm, Treg
	Methylprednisolone	B cell, Pre-B2 cell, DC, macrophage, monocyte, neutrophil, NK cell, Tm, Tn, Treg
	Cyclophosphamide	Bm, DC, macrophage, monocyte, NK cell, PBMC, Th1, Th17, Tm, Tn
Common; Drugs	Mycophenolate-mofetil	B cell, DC, neutrophil, NK cell, PBMC, Treg, Th1, Th2, Tm
	Azathioprine	B cell, DC, macrophage, monocyte, neutrophil, PBMC, Th1, Th2, Tm, Treg
	Hydroxychloroquine	Plasma cell, CD21B cell, Bms, Bn, macrophage, monocyte, neutrophil, NK cell, PBMC, CTL, Th, Tm, Tn
	Tacrolimus	Bm, Pre-B1 cell, Pre-B2 cell, DC, macrophage, monocyte, PBMC, CTL, Th1, Th2, Tm, Treg
	Cyclosporin-a	Bm, B1 cell, Pre-B2cell, DC, macrophage, monocyte, neutrophil, PBMC, CTL, Th1, Th2

Bn: naive B cell; Bm: memory B cell; Pre-B cell: precursor B cell; Tn: naive T cell: Th: helper T cell; Tm: memory T cell; Treg: regulatory T cell; CTL: cytotoxic T lymphocyte; DC: dendritic cell; PBMC: peripheral blood mononuclear cell; NK cell: natural killer cell.