Antiinflammatory and Anticancer Properties of Grewia asiatica Crude Extracts and Fractions: A Bioassay-Guided Approach

Table 1

In vitro antioxidant and antiinflammatory potential of G. asiatica.

Fruit samples	In vitro antioxidant assays			In vitro antiinflammatory assays; (% inhibition at 300 μg/mL)			Anticancer assay; (IC50μg/mL)
	DPPH; (IC50μg/mL)	FRAP; (mmol/g)	H202; (%)	Heat-induced hemolysis	Egg albumin denaturation	Bovine serum albumin denaturation	MCF-7	HEp-2	NCI-H522
100% DCM				^ns	^ns	^ns	175	257	232
100% MeOH							86	126	107
Fraction B							61	141	95
GAMF3							52	162	67
50% MeOH							35	80	73
Fraction C							30	73	81
GAHAF5							26	51	63
Ascorbic acid				—
Quercetin				—
Diclofenac sodium	—						—
Methotrexate				—

Values are DCM extract =100% dichloromethane extract; 100% MeOH extract =100% methanolic extract; GAMF = G. asiatica methanolic fraction; 50% MeOH extract = methanol : water (50 : 50 v/v); GAHAF = G. asiatica hydroalcoholic fraction; DPPH = 2,2-diphenyl-1-picrylhydrazyl; FRAP = ferric reducing antioxidant power; TPTZ = 2,4,6-tripyridyl-s-triazine; H₂O₂ = hydrogen peroxide , , , .