Research Article
Expression of Matrix Metalloproteinase-7 Predicts Poor Prognosis in Gastric Cancer
Table 3
The association of MMP-7 status and clinicopathological outcome of gastric cancer.
| Gastric mucosal pathology | MMP-7 status | OR; 95% CI | value | Low expression () | High expression () |
| Location of tumor (%) | | | Upper | 16 (13.67) | 44 (15.54) | 0.75 (0.61-0.92) | 0.229 | Middle | 41 (35.04) | 75 (26.50) | 0.71 (0.54-0.93) | 0.127 | Lower | 60 (51.28) | 164 (57.95) | 0.86 (0.71-1.14) | 0.573 | Tumor size (%) | | | | | <70 mm | 68 (58.12) | 153 (54.06) | 0.67 (0.52-0.84) | 0.872 | ≥70 mm | 49 (41.88) | 130 (45.93) | 0.71 (0.64-0.92) | 0.791 | Histologic type (%) | | | | | Differentiated | 82 (70.08) | 94 (33.21) | 0.96 (0.67-1.08) | 0.092 | Undifferentiated | 35 (29.91) | 189 (66.78) | 2.89 (1.57-4.94) | 0.018 | Lymphatic invasion (%) | | | | | Absent | 99 (84.61) | 64 (22.61) | 0.37 (0.14-0.76) | 0.028 | Present | 18 (15.38) | 219 (77.38) | 9.87 (5.57-13.29) | 0.019 | Vascular invasion (%) | | | | | Absent | 89 (76.06) | 52 (18.37) | 0.42 (0.21-0.83) | 0.017 | Present | 28 (23.93) | 231 (81.62) | 8.16 (4.87-10.19) | 0.015 | Pathological TNM stage (%) | | | | | I | 8 (6.83) | 21 (7.42) | 0.88 (0.69-0.97) | 0.826 | II | 25 (21.36) | 32 (11.30) | 0.91 (0.88-1.19) | 0.482 | III | 52 (44.44) | 86 (30.38) | 0.69(0.54-0.83) | 0.257 | IV | 32(27.35) | 144(50.88) | 1.95 (1.04-3.08) | 0.042 | Residual tumor (%) | () | () | | | Microscopic | 3 (33.33) | 8 (36.36) | 0.72 (0.54-0.93) | 0.628 | Gross (unresectable) | 6 (66.66) | 14 (63.63) | 0.68 (0.41-0.84) | 0.712 | CEA (%) | | | | | <5.0 (ng/ml) | 101 (86.32) | 67 (23.67) | 0.38 (0.19-0.69) | 0.036 | ≥5.0 (ng/ml) | 16 (13.67) | 216 (76.32) | 3.96 (1.68-5.27) | 0.012 |
|
|
Univariate regression model analysis. considered as statistically significant. |