Research Article
[Retracted] Synthesis and Evaluation of Finasteride-Loaded HPMC-Based Nanogels for Transdermal Delivery: A Versatile Nanoscopic Platform
Table 3
Results of skin irritation and toxicological studies.
(a) |
| | Irritation test results on rabbits |
| | Formulation applied | Time of observation | | 24 h | 48 h | 72 h | 240 h | | Control | 1 | — | — | — | — | | 2 | — | — | — | — | | 3 | — | — | — | — |
| | HPMC nanogels | 1 | — | — | — | — | | 2 | — | — | — | — | | 3 | — | — | — | — |
| | Irritation scale | | Sign | — | + | ++ | +++ | ++++ | | Outcome | None | Very slight | Well defined | Moderate | Eschar formation |
|
|
(b) |
| | Liver, kidney, and lipid profile | | Parameter | Control | Nanogels |
| | ALT (SGPT) (U/l) | | | | AST (SGOT) (U/l) | | | | Serum urea (mg/dl) | | | | Serum creatinine (mg/dl) | | | | Serum uric acid (mg/dl) | | | | Total cholesterol (mg/dl) | | | | Triglycerides (mg/dl) | | |
|
|
(c) |
| | Effect of nanogel administration on organ weights (g) of rabbits () | | Groups | Heart | Liver | Lung | Kidney | Spleen |
| | Control | | | | | | | Nanogels | | | | | |
|
|
(d) |
| | Haematological analysis | | Parameter | Control | Nanogels treated |
| | Hb (g/dl) | | | | pH | | | | RBCs (×106/mm3) | | | | TLC (×103/mm3) | | | | Eosinophil (%) | | | | Neutrophils (%) | | | | Monocytes (%) | | | | Lymphocytes (%) | | | | PLT (×103/mm3) | | | | MCV (fl) | | | | MCH (pg/cell) | | | | MCHC (g/dl) | | |
|
|
|
