Towards the First Multiepitope Vaccine Candidate against Neospora caninum in Mouse Model: Immunoinformatic Standpoint

Figure 7

Schematic representation of the molecular interactions between the chimeric vaccine and mouse TLR4, where E blue sphere is the chimeric vaccine and other four spheres belong to the receptor. (a) Interacting chains are linked by colored lines, each representing different type of interaction. Red denotes for salt bridges, blue for hydrogen bonds, and orange for nonbonded contacts. The size of each circle is proportional to the surface area of the corresponding protein chain. The extent of the interface region contacting the other chain is represented by a colored wedge whose color corresponds to the color of the other contacting chain and whose size signifies the interface surface area; (b) Blue line denotes hydrogen bond, red denotes salt bridge, and orange striped lines denote nonbonded contacts. In cases which the nonbonded contacts are plentiful, the width of the striped line increases depending on the number of the nonbonded contacts.