Cardioprotection by Citrus grandis (L.) Peel Ethanolic Extract in Alloxan-Induced Cardiotoxicity in Diabetic Rats

Figure 5

Histology of cardiac tissue. Cardiac photomicrograph (45x) showing usual anatomy with well-preserved cytoplasm. Diabetic control cardiac tissue shows clear penetration of inflammatory cells, the existence of lipid accumulation, swelling, ruptured, edema, and necrosis as indicated by arrows. Treatment with CGPE or Glib showed reduced, absence of lipid accumulation, inflammatory cells, and inflammation in cardiac tissue, the inflammatory cells decrease considerably, and partial cardiac tissue recovery is observed as shown by the arrows but shows some swollen and ruptured cells with lipid accumulation. There is a significant decrease in lipid accumulation, necrosis, and partial recovery of inflammatory cells, swollen, ruptured, and edema.