Synergistic Impacts of Alpinia oxyphylla Seed Extract and Allopurinol against Experimental Hyperuricemia

Figure 5

Effects of allopurinol, Alpinia oxyphylla seed extract (AE), and their combination on serum levels (a) and kidney protein expression (b) of IL-1β in hyperuricemic rats. Protein levels were measured by western blot analysis normalized to β-actin. (c) Renal histopathological changes (original magnification ×100) shown by hematoxylin and eosin staining. per group. NC: normal control; PO group: induced with potassium oxonate; AP: allopurinol (1 mg/kg); AE (200 mg/kg); AP + AE: AP (1 mg/kg) plus allopurinol (200 mg/kg). # and ## compared with the NC group; and compared with the PO group.

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