Category Term Description Log ( Gene name GO biological processes GO:0030335 Positive regulation of cell migration -41.57 AKT1, ALOX12, APP, SCARB1, MAPK14, EGFR, F3, FGF2, FGFR1, FLT1, MTOR, HIF1A, HMOX1, HRAS, ICAM1, IGF1R, IL6, CXCL8, INSR, ITGA2B, ITGA4, ITGB3, JAK2, KDR, LGALS3, MET, MMP9, MMP14, NOS3, SERPINE1, PDGFRB, PGF, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PRKCA, MAPK1, MAPK3, PTGS2, PTPRC, RET, SELP, SRC, TEK, TERT, TGFBR2, TLR4, TNF, VEGFA, PLA2G7, AKT3, SIRT1, NOX4, CCR2, AGTR1, ALOX5, EDNRA, EPAS1, EPHB4, HK2, JUN, MMP2, PIK3CA, PPARG, PRKCB, SHH, EIF2AK3, AHR, APOB, LDLR, AR, CCND1, ERN1, ESR1, MEN1, VDR, and AGTR2 GO biological processes GO:0010035 Response to inorganic substance -37.67 ADA, PARP1, AKT1, AKR1B1, APOB, APP, CCND1, BRAF, CA2, CASP3, CASP9, CDK4, CYP1A2, DNMT3A, DRD2, EGFR, ERN1, FABP4, FABP1, G6PD, HIF1A, HMOX1, ICAM1, IGFBP2, IL6, JUN, KDR, MAPT, MET, MMP3, MMP9, MPO, MTTP, NOS3, NTRK1, PDGFRB, PIK3CA, PON1, PRKCD, MAPK1, MAPK3, MAPK8, MAPK10, PTGS2, SHH, SLC5A1, SORD, SRC, TERT, VCAM1, EIF2AK3, and SIRT1 GO biological processes GO:1901652 Response to peptide -32.80 PARP1, ADRB2, AGTR1, AGTR2, AKT1, AKR1B1, APP, CA2, CDK4, MAPK14, MTOR, GCGR, GCK, HSD11B2, ICAM1, IGF1R, IGFBP1, INSR, ITGA4, JAK2, KCNQ1, MC4R, MEN1, MMP2, MMP3, MMP9, NTRK1, PIK3CA, PIK3R1, PPARA, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, PTPN2, RPS6KB1, SLC2A1, SRC, TEK, TLR4, TP53, VCAM1, TRPV1, NAMPT, SIRT1, ACHE, ADCY5, AHR, CASP3, CFTR, DNMT3A, DRD2, PIK3CG, MAPK1, MAPK3, TNF, NOX4, APOB, AR, CASP9, EGFR, ESR1, NR3C1, IGFBP2, NR3C2, PGF, and REN GO biological processes GO:0007169 Transmembrane receptor protein tyrosine kinase signaling pathway -32.25 ADRB2, AGTR2, AKT1, AR, BLK, BRAF, CASP3, CDK4, MAPK14, EGFR, EPHB4, F3, FGF2, FGFR1, FLT1, HIF1A, IGF1R, IGFBP1, IGFBP2, IGFBP3, INSR, ITGB3, JAK2, KDR, MET, MMP2, MMP9, NTRK1, PDGFRB, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PLAT, PRKCB, PRKCD, MAPK1, PTPN1, PTPN2, RET, RPS6KB1, SRC, TEK, VEGFA, EIF2AK3, NAMPT, MERTK, SIRT1, APP, CCND1, ACE, DRD2, ELANE, ERN1, F2, MTOR, HRAS, ICAM1, IL2, IL6, MIF, PIK3CG, PPARG, MAPK3, PTGS2, PTPRC, TGFBR2, TLR4, TNF, TNFRSF1A, TP53, CHEK2, NOX4, TLR9, FABP4, HMGCR, MAPT, MEN1, NEK2, ADRB3, CCR5, MMP8, PRKCA, MAPK8, MAPK10, REN, SIRT3, SELP, and PPARA GO biological processes GO:0009991 Response to extracellular stimulus -31.97 ACACB, ADA, ADRB2, AKT1, CCND1, CNR1, CPT1A, CYP27B1, DNMT3A, EGFR, MTOR, G6PD, GCGR, HMGCR, HMOX1, HSD11B2, ICAM1, IGFBP2, ITGA4, JUN, LDLR, MC4R, MPO, NTRK1, PON1, PPARA, PPARG, MAPK1, MAPK3, MAPK8, PTGS2, PTPRC, RPS6KB1, SLC2A1, SORD, SRC, TGFBR2, TP53, NR1H2, VCAM1, VDR, TRPV1, EIF2AK3, NAMPT, SIRT1, ALOX12, APP, CASP9, MAPK14, FGF2, HRAS, IGFBP1, MIF, SERPINE1, PDGFRB, PRKCD, MAPK10, TERT, AKT3, CHEK2, SIRT3, NOX4, CASP1, TLR4, and TNFRSF1A GO biological processes GO:0010942 Positive regulation of cell death -30.47 PARP1, AGTR2, AKT1, ALOX12, BLK, CASP3, CASP9, CDK4, CNR1, CTSD, DNMT3A, MTOR, HMGCR, HMOX1, IGFBP3, IL6, ITGA4, ITGB2, JAK2, JUN, MAPT, MMP3, MMP9, COX2, NOS2, NTRK1, PDGFRB, PIK3CB, PIK3CD, PPARG, PRF1, PRKCD, MAPK8, PTGS2, PTPN2, PTPRC, RET, SRC, TLR4, TNF, TNFRSF1A, TP53, VDR, TRPV1, CHEK2, SIRT1, and NOX4 GO biological processes GO:0003013 Circulatory system process -29.98 ADA, ADRB2, ADRB3, AGTR1, AGTR2, AKT1, AR, AVPR2, CACNA1C, CD38, CNR1, ACE, DRD2, EDNRA, EGFR, EPAS1, MTOR, GCGR, HMGCR, HMOX1, HSD11B2, ICAM1, IL2, INSR, JAK2, KCNJ5, KCNQ1, MTNR1B, NOS2, NOS3, PIK3CA, PIK3CG, PPARA, PPARG, PTGS1, PTGS2, REN, SGK1, SLC2A1, SLC5A1, SRC, TEK, VEGFA, TRPV1, NAMPT, NOX4, CDK4, MAPT, PRKCD, RET, and AKT3 GO biological processes GO:0050878 Regulation of body fluid levels -29.57 ADA, AKR1B1, ALOX12, AVPR2, CCND1, BLK, CFTR, MAPK14, DRD2, EGFR, F2, F3, HIF1A, HK2, HNF4A, HSD11B2, IL6, ITGA2B, ITGB3, JAK2, MET, COX2, NOS3, SERPINE1, PIK3CA, PIK3CB, PIK3CG, PLAT, PLG, PRKCA, PRKCD, SELP, SHH, SRC, TLR4, NR1H2, VDR, VEGFA, MERTK, ALOX5, CASP3, SCARB1, FGF2, MTOR, HMGCR, HMOX1, HRAS, KDR, PDGFRB, PPARA, TGFBR2, TNF, NTRK1, and CCR2 GO biological processes GO:0070482 Response to oxygen levels -28.66 ADA, AKT1, CASP1, CASP3, CD38, CDK4, DNMT3A, DRD2, EDNRA, EPAS1, FABP1, MTOR, HIF1A, HK2, HMOX1, HSD11B2, ICAM1, MMP2, MMP14, NOS2, PDGFRB, PGF, PLAT, PPARA, PTGS2, SLC2A1, SRC, TEK, TERT, TGFBR2, TP53, VCAM1, VEGFA, VHL, NAMPT, SIRT1, and NOX4 GO biological processes GO:0002237 Response to molecule of bacterial origin -26.82 AKT1, APOB, CASP1, CASP3, CASP9, SCARB1, CDK4, CCR5, CNR1, MAPK14, CYP1A2, CYP27B1, ELANE, ICAM1, IL6, CXCL8, JAK2, JUN, MPO, NOS2, NOS3, SERPINE1, PRKCA, MAPK1, MAPK3, MAPK8, PTGS2, REN, SELE, SELP, SRC, TLR4, TNF, VCAM1, TLR9, NLRP3, F2, FABP4, PRKCD, TNFRSF1A, TP53, EIF2AK3, KCNJ11, PTPN2, TRPV1, SIRT1, F3, HIF1A, PPARG, PTPN1, PTPRC, NR1H2, and CCR2 GO biological processes GO:0062197 Cellular response to chemical stress -26.59 PARP1, AKT1, AKR1B1, ALOX5, CASP3, EGFR, EPAS1, ERN1, FABP1, G6PD, HIF1A, HMOX1, IL6, JAK2, JUN, MAPT, MET, MMP2, MMP3, MMP9, MPO, NOS3, PIK3CA, PRKCD, MAPK1, MAPK3, MAPK8, MAPK10, PTGS2, SLC2A1, SRC, TLR4, TP53, EIF2AK3, SIRT1, ADA, APP, CD38, MMP14, PDGFRB, PTGS1, FGF2, IL2, NEK2, PTPRC, and MEN1 GO biological processes GO:0050727 Regulation of inflammatory response -25.79 ADA, AGTR1, ALOX5, APP, CASP1, CNR1, MAPK14, EGFR, ELANE, ESR1, FABP4, IL2, IL6, JAK2, LDLR, MMP3, MMP8, MMP9, SERPINE1, PIK3CG, PPARA, PPARG, PRKCD, PTGS2, PTPN2, PTPRC, SELE, SRC, TEK, TLR4, TNF, TNFRSF1A, PLA2G7, TLR9, NLRP3, CCR2, DRD2, MAPK3, PTPN1, NR1H2, F2, F3, FGF2, FGFR1, CXCL8, KDR, MET, PDGFRB, PGF, PLG, PRKCA, MAPK1, VEGFA, AGTR2, HIF1A, HK1, HMOX1, HRAS, MIF, NOS2, PIK3CD, PIK3R1, EIF2AK3, SIRT1, and MERTK GO biological processes GO:0018108 Peptidyl-tyrosine phosphorylation -25.12 APP, BLK, ACE, EGFR, EPHB4, FGFR1, FLT1, MTOR, ICAM1, IGF1R, IL2, IL6, INSR, ITGB2, ITGB3, JAK2, KDR, MET, MIF, NTRK1, PDGFRB, PRKCD, MAPK3, PTPN1, PTPN2, PTPRC, RET, SRC, TEK, TNF, TNFRSF1A, TP53, VEGFA, MERTK, NOX4, AKT1, ERN1, NEK2, EIF2AK3, and CHEK2 GO biological processes GO:0010817 Regulation of hormone levels -24.12 ADCY5, AGTR1, AGTR2, AKR1B1, ALOX5, BLK, SCARB1, CD38, CFTR, CNR1, CPT1A, CYP1A2, CYP2C9, CYP2D6, CYP3A4, CYP19A1, CYP27B1, ACE, DRD2, EGFR, ESR1, GCK, HIF1A, HMGCR, HNF4A, IL6, JAK2, KCNJ11, KCNQ1, MTNR1B, NOS2, RBP4, REN, SHH, TNF, TTR, SIRT3, AKR1B10, ACHE, MAPK14, CTSD, HRAS, ITGB2, MAPT, PIK3R1, PRKCD, MAPK1, MAPK8, PTGS2, PTPN1, SRC, TLR4, NR1H2, ADA, AVPR2, HMOX1, PRKCB, SGK1, TNFRSF1A, TRPV1, CCR2, GCGR, MTTP, PIK3CD, PIK3CG, MERTK, and CA2 GO biological processes GO:0097190 Apoptotic signaling pathway -24.10 PARP1, AGTR2, AKT1, AR, CASP1, CASP3, CASP9, CD38, ERN1, FGFR1, HIF1A, HMOX1, HRAS, ICAM1, IL2, JAK2, JUN, LGALS3, MIF, MMP9, NOS3, SERPINE1, PIK3R1, PRKCA, PRKCD, MAPK8, PTGS2, PTPN1, PTPN2, PTPRC, RET, SHH, SRC, TERT, TNF, TNFRSF1A, TP53, EIF2AK3, CHEK2, SIRT1, APP, CCND1, MAPK14, DNMT3A, DRD2, EGFR, ELANE, MTOR, HMGCR, MEN1, MMP1, MMP2, MMP3, NTRK1, MAPK10, VCAM1, NAMPT, NOX4, AKR1B1, PIK3CA, MAPK3, SLC2A1, TLR4, TRPV1, ALOX5, IGF1R, MAPT, MET, MMP8, MAPK1, NR1H2, VEGFA, AKT3, and TLR9 GO biological processes GO:0050900 Leukocyte migration -24.10 ADA, AKT1, ALOX5, APP, CCR5, ELANE, FLT1, HMOX1, ICAM1, IL6, CXCL8, ITGA2B, ITGA4, ITGB2, LGALS3, MIF, MMP9, MMP14, SERPINE1, PGF, PIK3CD, PIK3CG, MAPK1, MAPK3, RET, SELE, SELP, SRC, TNF, VCAM1, VEGFA, PLA2G7, NLRP3, CCR2, AGTR1, MAPK14, EPHB4, F3, FGF2, FGFR1, GLI2, HRAS, ITGB3, KDR, MET, NTRK1, PDGFRB, PIK3CB, PRKCD, PTPN2, and SHH GO biological processes GO:0030155 Regulation of cell adhesion -24.01 ADA, AKT1, ALOX12, ALOX5, BLK, CASP3, MAPK14, ELANE, GLI2, ICAM1, IGFBP2, IL2, IL6, CXCL8, ITGA4, ITGB2, JAK2, KDR, LGALS3, MEN1, MMP14, SERPINE1, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PLG, PPARA, PRKCA, PRKCD, PTPN2, PTPRC, RET, SELE, SELP, SHH, SRC, TEK, TGFBR2, TNF, VCAM1, VEGFA, NLRP3, CCR2, PARP1, APP, CA2, FASN, MTOR, GLO1, JUN, MMP9, NTRK1, PIK3CD, PPARG, TLR4, TP53, MERTK, SIRT1, TLR9, AHR, CD38, CNR1, F2, HMOX1, LDLR, MIF, MMP8, NOS3, PDGFRB, PRF1, PRKCB, ACE, HK1, MPO, NOS2, RBP4, MAPK1, MAPK3, HIF1A, HRAS, and APOB GO biological processes GO:0071396 Cellular response to lipid -23.27 ADCY5, PARP1, AGTR2, AHR, AKT1, ALOX12, AR, CASP1, CASP9, SCARB1, CDK4, CFTR, CCR5, CPT1A, MAPK14, CYP27B1, EGFR, ESR1, NR3C1, ICAM1, IL6, CXCL8, JAK2, LDLR, NR3C2, NOS2, SERPINE1, PPARA, PRKCA, MAPK1, MAPK3, MAPK8, RET, SRC, TLR4, TNF, VDR, SIRT1, NLRP3, APP, CASP3, DRD2, GLI2, KCNQ1, PIK3CG, PTGS2, TRPV1, CHEK2, NOX4, CCND1, CA2, CD38, HSD11B2, IGFBP2, TGFBR2, AKR1B1, and KCNJ11 GO biological processes GO:0048661 Positive regulation of smooth muscle cell proliferation -23.04 AKT1, AKR1B1, ALOX12, EGFR, ELANE, ERN1, FGF2, MTOR, HMGCR, HMOX1, IL6, JAK2, JUN, MMP2, MMP9, PDGFRB, PTGS2, TERT, TGFBR2, TLR4, TNF, NAMPT, MAPK14, IGFBP3, PPARG, MAPK1, RBP4, and SHH GO biological processes GO:0048871 Multicellular organismal homeostasis -22.95 ACACB, ACHE, ADRB2, ADRB3, AKR1B1, ALOX12, CA2, CD38, CFTR, CNR1, CPT2, DRD2, EGFR, EPAS1, FABP4, IGF1R, IL6, ITGB3, JAK2, MC4R, MET, NOS3, PIK3CA, PRKCA, PTGS2, RBP4, SCD, SLC2A1, SRC, TLR4, TNF, NR1H2, VEGFA, TRPV1, AKT3, TLR9, CCR2, AGTR2, ACE, HIF1A, IL2, MMP2, MMP14, PLG, TP53, and VDR GO cellular components GO:0045121 Membrane raft -19.04 APP, CASP3, SCARB1, CNR1, CTSD, EGFR, HK1, HMOX1, ICAM1, INSR, ITGB2, JAK2, KCNQ1, KDR, MAPT, NOS3, MAPK1, MAPK3, PTGS2, PTPRC, RET, SELE, SHH, SLC2A1, SRC, TEK, TGFBR2, TNF, and TNFRSF1A GO cellular components GO:0043235 Receptor complex -14.82 ADRB2, ADRB3, AHR, APP, EGFR, EPHB4, FGFR1, FLT1, IGF1R, IL6, INSR, ITGA2B, ITGA4, ITGB2, ITGB3, KDR, LDLR, MET, NR3C2, MTTP, NTRK1, PDGFRB, PPARG, RET, TEK, TGFBR2, TLR4, TNFRSF1A, VDR, and MERTK GO cellular components GO:0098552 Side of membrane -11.10 ACP1, ADA, AKT1, BLK, CA4, CCR5, ACE, F2, F3, G6PD, ICAM1, INSR, ITGA2B, ITGB2, KCNJ5, LDLR, PLG, PTPN1, PTPRC, SELE, SELP, SRC, TGFBR2, TLR4, TNF, VCAM1, TRPV1, and CCR2 GO cellular components GO:0045177 Apical part of cell -9.49 ADRB2, APP, CA2, CA4, CFTR, EGFR, FABP1, IGFBP2, KCNQ1, LDLR, PDGFRB, PLAT, REN, SI, SLC2A1, SLC2A2, SLC5A1, TEK, VCAM1, MGAM, NOX4, TLR9, CD38, MET, and MTTP GO cellular components GO:0031983 Vesicle lumen -8.16 ADA, ALOX5, APOB, APP, MAPK14, CTSD, EGFR, ELANE, IMPDH1, MIF, MMP8, MPO, SERPINE1, PLG, PRKCD, MAPK1, TTR, VEGFA, ADRB2, AKR1B1, SCARB1, CFTR, ACE, MTOR, INSR, KCNQ1, LDLR, PDGFRB, PRF1, SRC, TLR9, and AKR1B10 GO cellular components GO:0048471 Perinuclear region of cytoplasm -6.18 ACHE, AGTR2, AKR1B1, ALOX5, APP, AVPR2, CA4, CDK4, EGFR, HMOX1, HRAS, NOS2, PIK3CA, PIK3R1, PRKCA, PRKCD, SELE, SLC5A1, SRC, TLR4, EIF2AK3, NOX4, and CCR2 GO cellular components GO:0005769 Early endosome -6.07 ADRB2, APOB, APP, CFTR, EGFR, KCNQ1, KDR, LDLR, NTRK1, MAPK1, MAPK3, PTPN1, RET, SLC5A1, TLR4, VCAM1, AOC3, AVPR2, SCARB1, DRD2, ELANE, MTOR, MPO, NOS3, TLR9, INSR, SRC, and CTSD GO cellular components GO:0043025 Neuronal cell body -5.40 ADA, APOB, APP, CACNA1C, CASP3, DRD2, MTOR, INSR, ITGA4, KCNJ11, KCNQ1, MAPT, NTRK1, MAPK1, MAPK10, RET, TRPV1, CCR2, CA2, CNR1, HIF1A, IGF1R, PRKCB, MAPK8, AKT1, ITGB3, JAK2, and SRC GO cellular components GO:0031012 Extracellular matrix -5.39 ACHE, CTSD, ELANE, F2, F3, ICAM1, LGALS3, MMP1, MMP2, MMP3, MMP8, MMP9, MMP14, SERPINE1, PLAT, PLG, PRSS1, SHH, and VEGFA GO cellular components GO:0005925 Focal adhesion -5.10 EGFR, FLT1, ICAM1, ITGA2B, ITGA4, ITGB2, ITGB3, JAK2, MMP14, PDGFRB, MAPK1, MAPK3, PTPRC, SRC, TEK, NOX4, CACNA1C, CASP3, IGF1R, IL6, INSR, KCNJ1, KCNJ5, KCNJ11, KCNQ1, PRKCA, RET, VCAM1, and SELP GO cellular components GO:0005902 Microvillus -4.57 AKR1B1, CA2, SCARB1, ITGB3, MTTP, TEK, VCAM1, AOC3, and APP GO cellular components GO:0005943 Phosphatidylinositol 3-kinase complex, class IA -4.53 PIK3CA, PIK3CG, PIK3R1, PIK3CB, PIK3CD, AKT1, BLK, PLG, and SRC GO cellular components GO:0101002 Ficolin-1-rich granule -4.12 ALOX5, MAPK14, CTSD, IMPDH1, ITGB2, LGALS3, MIF, MMP9, MAPK1, MGAM, and MMP8 GO cellular components GO:0061695 Transferase complex, transferring phosphorus-containing groups -4.03 CCND1, CDK4, ERN1, IGF1R, INSR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, TERT, and MEN1 GO cellular components GO:0005788 Endoplasmic reticulum lumen -3.72 APOB, APP, F2, IGFBP1, IGFBP3, IL6, MEN1, MTTP, MAPK1, MAPK3, PTGS2, and SHH GO cellular components GO:0005911 Cell-cell junction -3.71 AKT1, AKR1B1, APP, CCND1, CDK4, ITGB3, KCNJ11, PIK3CA, PIK3R1, PRKCD, SLC2A1, SLC2A2, SLC5A1, TEK, and VEGFA GO cellular components GO:0031091 Platelet alpha granule -3.62 APP, ITGA2B, ITGB3, SERPINE1, PLG, SELP, and VEGFA GO cellular components GO:0034358 Plasma lipoprotein particle -3.55 APOB, CETP, LDLR, PON1, and PLA2G7 GO cellular components GO:0031968 Organelle outer membrane -3.48 ACACB, CNR1, CPT1A, CYP27B1, MTOR, HK1, HK2, HMOX1, PTGS2, RPS6KB1, CPT2, LGALS3, COX2, PRKCA, PTPN1, SORD, and SRC GO cellular components GO:0097443 Sorting endosome -3.48 KDR, LDLR, PTPN1, PRKCD, and TLR9 GO cellular components GO:0016773 Phosphotransferase activity, alcohol group as acceptor -24.541 AKT1, CCND1, BLK, BRAF, CDK4, MAPK14, EGFR, EPHB4, ERN1, FGFR1, FLT1, MTOR, GCK, HK1, HK2, IGF1R, INSR, JAK2, KDR, MET, NEK2, NTRK1, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKCA, PRKCB, PRKCD, MAPK1, MAPK3, MAPK8, MAPK10, RET, RPS6KB1, SGK1, SRC, TEK, TGFBR2, EIF2AK3, AKT3, MERTK, and CHEK2 GO molecular functions GO:0019900 Kinase binding -13.744 PARP1, AKT1, CCND1, CASP1, CASP9, MAPK14, ACE, EGFR, ESR1, MTOR, NR3C1, HIF1A, ITGB2, JAK2, KCNQ1, KIF11, MAPT, NTRK1, PDGFRB, PIK3R1, PLG, PRKCB, PRKCD, MAPK1, PTPN1, PTPN2, PTPRC, SLC2A1, SRC, TGFBR2, TP53, CHEK2, SIRT1, and NOX4 GO molecular functions GO:0019199 Transmembrane receptor protein kinase activity -13.577 BLK, EGFR, EPHB4, FGFR1, FLT1, IGF1R, INSR, JAK2, KDR, MET, NTRK1, PDGFRB, PRKCD, RET, SRC, TEK, TGFBR2, MERTK, IGFBP1, IGFBP2, IGFBP3, and ITGB3 GO molecular functions GO:0020037 Heme binding -11.563 CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP19A1, CYP27B1, HMOX1, JAK2, MPO, NOS2, NOS3, PTGS1, PTGS2, SRC, NOX4, ALDH2, AKR1B1, ALOX12, ALOX5, FASN, G6PD, HMGCR, HSD11B1, HSD11B2, IMPDH1, COX2, SCD, SORD, VCAM1, AOC3, and AKR1B10 GO molecular functions GO:0008134 Transcription factor binding -10.270 PARP1, AHR, AR, CCND1, MAPK14, DNMT3A, EPAS1, ESR1, MTOR, GLI2, HIF1A, HNF4A, JUN, PIK3R1, PPARA, PPARG, PRKCB, PTPN2, SRC, TERT, TP53, NR1H2, VDR, VHL, SIRT1, NLRP3, NR3C1, NR3C2, EGFR, FABP1, MEN1, and MPO GO molecular functions GO:0019902 Phosphatase binding -9.464 AKT1, MAPK14, EGFR, HMGCR, KCNQ1, LGALS3, MAPT, MET, NEK2, PIK3R1, PPARA, MAPK1, MAPK3, PTPN1, TP53, and EIF2AK3 GO molecular functions GO:0043560 Insulin receptor substrate binding -7.850 IGF1R, INSR, JAK2, PIK3CA, PIK3R1, PRKCD, AR, EGFR, GCGR, NR3C1, MC4R, SHBG, TTR, PDGFRB, and REN GO molecular functions GO:0005539 Glycosaminoglycan binding -7.446 APOB, APP, ELANE, F2, FGF2, FGFR1, HK1, MPO, PGF, PTPRC, SELP, SHH, TGFBR2, VEGFA, NLRP3, ACACB, GSTM1, and TKT GO molecular functions GO:0031994 Insulin-like growth factor I binding -7.346 IGF1R, IGFBP1, IGFBP2, IGFBP3, INSR, and ITGB3 GO molecular functions GO:0017171 Serine hydrolase activity -7.206 ACHE, ACE, ELANE, F2, F3, MMP1, MMP2, MMP3, MMP8, MMP9, MMP14, PLAT, PLG, PRSS1, CASP1, CASP3, CASP9, CTSD, REN, and SHH GO molecular functions GO:0070851 Growth factor receptor binding -7.012 APP, ERN1, FGF2, IL2, IL6, ITGB3, JAK2, PDGFRB, PGF, SRC, VEGFA, TLR9, CASP3, CXCL8, MIF, NTRK1, PIK3R1, TGFBR2, TNF, CCR2, LGALS3, AGTR2, F2, SHH, TTR, and NAMPT GO molecular functions GO:0005178 Integrin binding -6.955 EGFR, FGF2, ICAM1, ITGA4, ITGB2, ITGB3, KDR, MMP14, PRKCA, PTPN2, SRC, VCAM1, FASN, and PTPN1 GO molecular functions GO:0004712 Protein serine/threonine/tyrosine kinase activity -6.852 AKT1, BRAF, MAPK14, MAPK1, MAPK3, MAPK10, RPS6KB1, SGK1, MAPK8, MTOR, MEN1, PIK3R1, PLAT, SRC, and TRPV1 GO molecular functions GO:0005496 Steroid binding -6.384 AR, CETP, CYP3A4, ESR1, NR3C1, HSD11B1, HSD11B2, NR3C2, SHBG, and VDR GO molecular functions GO:0042803 Protein homodimerization activity -5.530 ACHE, ADRB2, ADRB3, AHR, AKT1, ERN1, FGFR1, G6PD, GSTM1, HMOX1, HNF4A, HSD11B1, NOS2, NTRK1, PON1, PTGS2, TERT, TKT, VEGFA, CHEK2, and TLR9 GO molecular functions GO:0051879 Hsp90 protein binding -5.503 AHR, ERN1, NR3C1, HIF1A, KDR, MAPT, EIF2AK3, ITGB2, KCNJ11, and PPARG GO molecular functions GO:0033218 Amide binding -5.214 ACACB, ACHE, ADRB2, AVPR2, SCARB1, FASN, GCGR, GSTM1, IGF1R, INSR, ITGB2, LDLR, MC4R, PIK3R1, PPARG, and TLR4 GO molecular functions GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity -5.050 PIK3CA, PIK3CB, PIK3CD, and PIK3CG GO molecular functions GO:0031406 Carboxylic acid binding -4.940 ACACB, FABP4, FABP1, FABP2, HNF4A, NOS2, NOS3, PPARG, SELE, SELP, VDR, and NR1H2 GO molecular functions GO:0055056 D-glucose transmembrane transporter activity -4.579 SLC2A1, SLC2A2, SLC5A1, SLC5A2, and RBP4
