Identification of Potential Molecular Targets and Active Ingredients of Mingmu Dihuang Pill for the Treatment of Diabetic Retinopathy Based on Network Pharmacology

Table 2

KEGG pathway enrichment analysis of predicted target genes.

Term	Description	Log ( value)	Gene name
hsa05200	Pathways in cancer	-45.35	ADCY5, AGTR1, AKT1, AR, CCND1, BRAF, CASP3, CASP9, CDK4, EDNRA, EGFR, EPAS1, FGF2, FGFR1, MTOR, GLI2, HIF1A, HRAS, IGF1R, IL6, CXCL8, ITGA2B, JUN, MET, MMP1, MMP2, MMP9, NOS2, NTRK1, PDGFRB, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PPARG, PRKCA, PRKCB, MAPK1, MAPK3, MAPK8, MAPK10, PTGS2, RET, SHH, SLC2A1, TGFBR2, TP53, VEGFA, VHL, AKT3, MAPK14, F3, ICAM1, JAK2, NOS3, SERPINE1, PRKCD, SELE, TNF, VCAM1, NOX4, ESR1, FASN, ITGB3, KDR, RPS6KB1, SRC, TLR4, FLT1, HK1, HK2, HMOX1, INSR, TEK, G6PD, GCK, SLC2A2, SIRT3, CYP2D6, IL2, ITGA4, PIK3CG, SGK1, CNR1, DRD2, ITGB2, GSTM1, PLAT, TNFRSF1A, ACE, TLR9, CASP1, PLG, PRSS1, EIF2AK3, NLRP3, SCARB1, LDLR, PPARA, MMP3, MMP14, CACNA1C, KCNJ11, PARP1, CTSD, ERN1, PRF1, KCNJ5, SIRT1, ACACB, PTPN1, CFTR, CPT1A, HMGCR, HNF4A, SCD, COX2, PTGS1, TERT, CHEK2, AVPR2, F2, MAPT, HSD11B2, KCNJ1, NR3C2, ALOX5, SI, SLC5A1, MGAM, ADRB2, ADRB3, FABP4, ACHE, KCNQ1, PTPRC, ALOX12, TRPV1, CCR5, CCR2, CD38, PTPN2, and EPHB4
hsa04931	Insulin resistance	-26.36	ACACB, AKT1, CPT1A, MTOR, IL6, INSR, NOS3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PPARA, PRKCB, PRKCD, MAPK8, MAPK10, PTPN1, RPS6KB1, SLC2A1, SLC2A2, TNF, TNFRSF1A, NR1H2, AKT3, JAK2, GCGR, GCK, PRKCA, and SIRT1
hsa05219	Bladder cancer	-18.69	CCND1, BRAF, CDK4, EGFR, HRAS, CXCL8, MMP1, MMP2, MMP9, MAPK1, MAPK3, SRC, TP53, VEGFA, NTRK1, PPARG, RET, CASP3, DNMT3A, MTOR, HMOX1, ITGB3, MET, PDGFRB, PIK3CA, PRKCA, PRKCB, PTGS2, and SIRT1
ko05152	Tuberculosis	-17.81	AKT1, CASP3, CASP9, MAPK14, CTSD, CYP27B1, IL6, ITGB2, JAK2, NOS2, MAPK1, MAPK3, MAPK8, MAPK10, SRC, TLR4, TNF, TNFRSF1A, VDR, AKT3, TLR9, ALOX5, CCR5, LDLR, PIK3CG, CASP1, CXCL8, JUN, NLRP3, MMP1, MMP3, MMP9, PTGS2, ITGA4, PRKCB, AHR, MTOR, HIF1A, IL2, TGFBR2, PRKCD, NAMPT, EGFR, and MET
hsa04726	Serotonergic synapse	-17.25	ADCY5, ALOX12, ALOX5, APP, BRAF, CACNA1C, CASP3, CYP2C19, CYP2C9, CYP2D6, HRAS, KCNJ5, PRKCA, PRKCB, MAPK1, MAPK3, PTGS1, and PTGS2
hsa04912	GnRH signaling pathway	-16.35	ADCY5, CACNA1C, MAPK14, EGFR, HRAS, JUN, MMP2, MMP14, PRKCA, PRKCB, PRKCD, MAPK1, MAPK3, MAPK8, MAPK10, SRC, CCND1, CD38, KCNJ5, NOS3, PIK3CG, PTGS2, CNR1, DRD2, PDGFRB, AKT1, AKT3, AGTR1, BRAF, EDNRA, IGF1R, GCK, KCNJ11, SLC2A1, SLC2A2, MTNR1B, SCARB1, LDLR, SIRT1, PDE11A, and TTR
hsa04371	Apelin signaling pathway	-13.17	ADCY5, AGTR1, AKT1, CCND1, MTOR, HRAS, NOS2, NOS3, SERPINE1, PIK3CG, PLAT, PRKCA, MAPK1, MAPK3, RPS6KB1, AKT3, ADRB2, ADRB3, CACNA1C, EDNRA, INSR, PDE5A, AGTR2, MAPK14, KCNQ1, ACE, REN, CD38, EGFR, PDGFRB, and PRKCB
ko05144	Malaria	-12.56	ICAM1, IL6, CXCL8, ITGB2, MET, SELE, SELP, TLR4, TNF, VCAM1, TLR9, FLT1, JUN, MMP1, MMP3, TEK, VEGFA, FASN, PRKCA, PRKCB, PARP1, PTGS2, and TNFRSF1A
ko05202	Transcriptional misregulation in cancer	-11.80	ELANE, FLT1, IGF1R, IGFBP3, IL6, CXCL8, MEN1, MET, MMP3, MMP9, MPO, NTRK1, PLAT, PPARG, TGFBR2, and TP53
hsa04520	Adherens junction	-10.69	ACP1, EGFR, FGFR1, IGF1R, INSR, MET, MAPK1, MAPK3, PTPN1, SRC, TGFBR2, BRAF, RPS6KB1, TNF, IL6, ADCY5, and AR
hsa04976	Bile secretion	-9.14	ADCY5, CA2, SCARB1, CFTR, CYP3A4, HMGCR, LDLR, PRKCA, SLC2A1, SLC5A1, CD38, KCNQ1, PRKCB, PRSS1, and KCNJ1
hsa04080	Neuroactive ligand-receptor interaction	-9.05	ADRB2, ADRB3, AGTR1, AGTR2, AVPR2, CNR1, DRD2, EDNRA, F2, GCGR, NR3C1, MC4R, MTNR1B, PLG, PRSS1, and TRPV1
hsa04913	Ovarian steroidogenesis	-9.05	ADCY5, ALOX5, SCARB1, CYP19A1, IGF1R, INSR, LDLR, PRKCA, and PTGS2
hsa00052	Galactose metabolism	-8.08	AKR1B1, GCK, HK1, HK2, SI, MGAM, AKR1B10, ALDH2, G6PD, and TKT
hsa03320	PPAR signaling pathway	-8.00	CPT1A, CPT2, FABP4, FABP1, FABP2, MMP1, PPARA, PPARG, SCD, FASN, and ALDH2
hsa05010	Alzheimer’s disease	-7.75	APP, CACNA1C, CASP3, CASP9, ERN1, MAPT, COX2, MAPK1, MAPK3, TNF, TNFRSF1A, EIF2AK3, CASP1, IL6, CXCL8, ITGB2, TLR4, MAPK14, TP53, JAK2, JUN, MAPK8, MAPK10, and TLR9
hsa04144	Endocytosis	-7.57	ADRB2, ADRB3, CCR5, EGFR, FLT1, HRAS, IGF1R, KDR, LDLR, MET, NTRK1, RET, SRC, TGFBR2, IL2, IL6, CXCL8, PDGFRB, TNF, TNFRSF1A, VEGFA, and CCR2
ko04137	Mitophagy-animal	-7.09	HIF1A, HRAS, JUN, MAPK8, MAPK10, SRC, TP53, EIF2AK3, CCND1, PRKCA, PRKCB, CDK4, and CFTR
hsa04115	p53 signaling pathway	-6.89	CCND1, CASP3, CASP9, CDK4, IGFBP3, SERPINE1, TP53, CHEK2, ICAM1, ITGB2, and PRF1
hsanan01	Drug metabolism	-6.20	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, GSTM1, IMPDH1, MPO, SORD, HSD11B1, PTGS2, CYP19A1, and HSD11B2