In Silico Screening of Synthetic and Natural Compounds to Inhibit the Binding Capacity of Heavy Metal Compounds against EGFR Protein of Lung Cancer

Table 4

Molecular docking results of heavy metals’ compounds with EGFR protein.

S. #	MC	SV	RMSD	E-conf.
1	Tinidazole	-20.42	1.455	41.16
2	Thallium, bromodimethyl	-7.865	1.467	-18.09
3	Silver acetate	-7.748	2.361	-42.74
4	Mercuric cyanide	-6.323	3.830	-291.7
5	Arsenate	-5.700	1.149	-154.4
6	Tellurium hexafluoride	-5.396	0.570	-1139
7	Lead sulfide	-4.744	1.157	-71.08
8	Antimony trichloride	-4.256	1.131	-17.03
9	Vanadium tetrachloride	-4.209	1.266	-83.48
10	Chromium iodide	-4.109	1.414	-34.01
11	Bismuth trichloride	-3.693	0.563	-15.09
12	Platinum tetrachloride	-3.462	1.341	-36.47
13	Gold bromide	-3.339	1.369	-3.975
14	Manganese dioxide	-3.156	1.715	-120.8
15	Ferric chloride	-2.972	2.541	-23.12
16	Nickel chloride	-2.971	1.105	-39.53
17	Uranium trioxide	-2.951	0.733	-253.5
18	Cerium disulfide	-2.758	4.094	-61.50
19	Cobalt (II) bromide	-2.708	1.443	-64.85
20	Zinc diflouride	-2.007	1.256	-11.85
21	Gallium iodide	-1.951	0.935	-26.38
22	Cupric chloride	-1.825	2.994	-12.83
23	Cadmium bromide	-1.582	1.133	-11.94

MC: metal compounds; SV: scoring values (kcal/mol); RMSD values: root means square deviation (Å); E-conf: expected confirmation.