Diagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A Meta-analysis

Table 2

Subgroup analysis of serum CHI3L1 in diagnosing stages of liver fibrosis.

Subgroup	Significant fibrosis ()			Advanced fibrosis ()			Cirrhosis ()
	Sensitivity (95% CI)	Specificity (95% CI)	AUC	Sensitivity (95% CI)	Specificity (95% CI)	AUC	Sensitivity (95% CI)	Specificity (95% CI)	AUC
	82.5%	80.8%	—	93.1%	73.5%	—	89.5%	84.4%	—
Age
Under 40	0.83 (0.78-0.87)	0.84 (0.79-0.88)	0.92	0.93 (0.89-0.96)	0.90 (0.85-0.94)	0.50	0.86 (0.78-0.92)	0.66 (0.60-0.72)	0.85
	90.3%	0%	—	0%	0%	—	80.1%	32.9%	—
Over 40	0.75 (0.70-0.79)	0.80 (0.75-0.84)	0.82	0.70 (0.64-0.83)	0.79 (0.75-0.84)	0.50	0.68 (0.62-0.73)	0.82 (0.77-0.87)	0.50
	0%	91.3%	—	0%	0%	—	89.5%	77.9%	—
Aetiology
HBV	0.83 (0.78-0.87)	0.84 (0.79-0.88)	0.92	0.93 (0.89-0.96)	0.90 (0.85-0.94)	0.50	0.86 (0.78-0.92)	0.66 (0.60-0.72)	0.85
	90.3%	0	—	0%	0%	—	80.1%	32.9%	—
Other	0.75 (0.70-0.79)	0.80 (0.75-0.84)	0.82	0.70 (0.64-0.83)	0.79 (0.75-0.84)	0.50	0.68 (0.62-0.73)	0.82 (0.77-0.87)	0.50
	0	91.3%	—	0%	0%	—	89.5%	77.9%	—
Scoring system
METAVIR	0.80 (0.76-0.83)	0.81 (0.77-0.85)	0.88	0.76 (0.68-0.83)	0.88 (0.82-0.92)	0.50	0.87 (0.73-0.95)	0.72 (0.65-0.77)	0.83
	89.6%	92.0%	—	86.8%	76.6%	—	81.2%	46.8%	—
Other	0.76 (0.69-0.82)	0.83 (0.77-0.87)	0.91	0.83 (0.78-0.87)	0.81 (0.77-0.85)	0.50	0.70 (0.65-0.75)	0.76 (0.71-0.81)	0.50
	75.5%	0%	—	96.9%	66.7%	—	91.7%	89.6%	—