Association between Circulating Antioxidants and Longevity: Insight from Mendelian Randomization Study

Figure 2

Odds ratios for relationships between genetically predicted circulating antioxidants and longevity (). The ORs for absolute antioxidants represent the effect of per unit increase in ln-transformed selenium, β-carotene, and retinol values, 1 mmol/l ascorbate and 1 mg/dl lycopene, on longevity. For antioxidant metabolites, ORs represent the effect of per 10-fold increase in the antioxidant metabolite’s level on longevity. All estimates were calculated based on random-effect IVW method. The P_{heterogeneity} values derived from the Cochran’s statistics were used to reflect heterogeneity between the SNP-specific estimates. Abbreviations: CI: confidence interval; IVW: inverse-variance weighted; OR: odds ratio; SNP: single nucleotide polymorphism.