Research Article
[Retracted] Computational Insights into the Structural and Functional Impacts of nsSNPs of Bone Morphogenetic Proteins
Table 2
Prediction of functional outcomes of nsSNP in chicken BMP4.
| | | | | | SIFT | PolyPhen-2 | I-Mutant | PHD-SNPs | PROVEAN | | Variant ID | Location | Alleles | Consequence | AA | Prediction | Score | Prediction | Score | SVM2 effect | DDG | RI | Effects | RI | Prediction | Score |
| | rs737608757 | 5 : 58714930 | A/G | Missense | V357A | Deleterious | 0.00 | Probably damaging | 0.997 | Decrease | -1.77 | 9 | Disease | 9 | Deleterious | -3.648 | | rs732839481 | 5 : 58714961 | A/G | Missense | S347P | Deleterious | 0.00 | Probably damaging | 0.988 | Decrease | -0.15 | 3 | Disease | 7 | Deleterious | -3.817 | | rs734844742 | 5 : 58714969 | T/G | Missense | H344P | Deleterious | 0.00 | Probably damaging | 1.00 | Decrease | 0.13 | 3 | Disease | 5 | Deleterious | -9.096 | | rs741287624 | 5 : 58715180 | T/G | Missense | T274P | Deleterious | 0.00 | Probably damaging | 1.00 | Decrease | -0.65 | 7 | Disease | 2 | Deleterious | -5.855 | | rs730990074 | 5 : 58715182 | A/G | Missense | V273A | Deleterious | 0.00 | Probably damaging | 0.909 | Decrease | -1.64 | 9 | Disease | 6 | Deleterious | -3.59 | | rs313051524 | 5 : 58715219 | A/G | Missense | Y261H | Tolerated | 0.11 | Benign | 0.005 | Decrease | -1.2 | 6 | Disease | 7 | Neutral | 1.491 | | rs317399411 | 5 : 58715229 | T/G | Missense | L257F | Deleterious | 0.00 | Probably damaging | 1.00 | Decrease | -1.23 | 7 | Neutral | 6 | Deleterious | -2.543 | | rs740468830 | 5 : 58715281 | A/G | Missense | L240P | Tolerated | 0.42 | Probably damaging | 0.998 | Decrease | -0.97 | 4 | Neutral | 6 | Neutral | -0.595 | | rs731863862 | 5 : 58715333 | A/C | Missense | W223G | Deleterious | 0.00 | Probably damaging | 1.00 | Decrease | -2.36 | 9 | Disease | 7 | Deleterious | -11.743 | | rs738054003 | 5 : 58715355 | A/C | Missense | D215E | Deleterious | 0.00 | Probably damaging | 0.985 | Decrease | -0.15 | 5 | Neutral | 2 | Deleterious | -3.895 | | rs739999946 | 5 : 58715369 | A/C | Missense | W211G | Deleterious | 0.00 | Probably damaging | 1.00 | Decrease | -2.16 | 9 | Disease | 8 | Deleterious | -11.404 | | rs731128170 | 5 : 58715486 | A/C | Missense | W172G | Tolerated | 0.36 | Probably damaging | 0.865 | Decrease | -1.92 | 9 | Neutral | 7 | Neutral | 0.94 | | rs738537703 | 5 : 58715503 | T/C | Missense | E166G | Tolerated | 0.19 | Benign | 0.001 | Decrease | -1.09 | 7 | Neutral | 7 | Neutral | -1.046 | | rs739516377 | 5 : 58715506 | A/C | Missense | V165G | Deleterious | 0.04 | Probably damaging | 0.99 | Decrease | -1.63 | 7 | Neutral | 1 | Deleterious | -3.592 | | rs313359121 | 5 : 58715596 | A/G | Missense | V135A | Tolerated | 0.45 | Benign | 0.001 | Decrease | -1.95 | 9 | Neutral | 7 | Neutral | 0.55 | | rs733650353 | 5 : 58716514 | A/G | Missense | F120S | Deleterious | 0.00 | Probably damaging | 0.999 | Decrease | -1.68 | 8 | Disease | 6 | Deleterious | -5.932 | | rs741393694 | 5 : 58716530 | T/G | Missense | N115H | Deleterious | 0.00 | Probably damaging | 1.00 | Decrease | -0.67 | 8 | Disease | 0 | Deleterious | -3.673 | | rs317497962 | 5 : 58716842 | T/G | Missense | I11L | Tolerated | 1.00 | Benign | 0.001 | Decrease | -0.71 | | Neutral | 7 | Neutral | 0.442 |
|
|
