[Retracted] Computational Insights into the Structural and Functional Impacts of nsSNPs of Bone Morphogenetic Proteins

Table 5

Prediction of ligand-binding sites within BMP2 and BMP4 proteins using COACH.

BMP2	COACH results
	C-score	Cluster size	Ligands name	Predicted binding residue
	0.16	10	ZN	321, 325, 389, 391
	0.03	2	MG	145, 205, 262
	0.03	2	NAG	205, 207, 208, 211
	0.03	2	NI	58, 60, 348
	0.03	2	EDO	3, 6
	0.02	1	ZN	152, 232
	0.02	1	MG	300, 301
	0.02	1	PEPTIDE	354, 355, 356, 382, 392
	0.02	1	PEPTIDE	79, 82
	0.02	1	MG	56, 390
	TM-site
	C-score	Cluster size	Ligands name	Predicted binding residues
	0.18	2	Mg(1), ZN(1)	321, 325, 389, 391
	0.15	1	Mg(1)	300, 301
	0.13	1	C8E(1)	369, 377
	0.12	2	T55(1), EDO(1)	3, 6
	0.12	1	Mg(1)	145, 205, 262
	S-site
	C-score	Cluster size	Ligands name	Predicted binding residues
	0.32	9	Zn, FE, UUU	292, 294, 321, 325, 354, 355, 356, 357, 389, 391
	0.11	1	DIO	7, 309, 369
BMP4	COACH results
	C-score	Cluster size	Ligands name	Predicted binding residues
	0.1	6	ZN	333, 337, 368, 369
	0.05	3	Nuc.Acid	53, 56
	0.05	3	SIA	320, 322, 324, 325, 326
	0.03	2	k-mer	304, 306, 344, 346, 401
	0.03	2	CA	312, 313
	0.03	2	UNK	380, 382
	0.02	1	PEPTIDE	366, 367, 368, 394, 404
	0.02	1	N/A	113, 303, 304, 337, 340, 344, 346, 347, 356, 357
	0.02	1	BU2	116, 159, 269
	0.02	1	MAL	325, 378, 380, 392
	TM-site
	C-score	Cluster size	Ligands name	Predicted binding residues
	0.17	2	CA	312, 315
	0.15	3	NUC, MPG	53, 56
	0.13	1	UNK	380, 382
	0.13	1	EQU	393, 394
	0.12	1	CLA	62, 66
	S-site
	C-score	Cluster size	Ligands name	Predicted binding residues
	0.32	9	ZN, III, FE	304, 333, 344, 346, 366, 367, 368, 369, 394, 401
	0.11	1	DIO	319, 321, 381