Research Article
Preparation and Biocompatibility of Core-Shell Microspheres for Sequential, Sustained Release of BMP-2 and VEGF
Table 1
Preparation of different microspheres.
| | Group A | Group B | Group C | Group D | Group E | Group F |
| | Polymer type | PLLA (core)/PLGA (shell) | PLLA (core)/PLGA (shell) | PLLA (core)/PLGA (shell) | PLLA (core)/PLGA (shell) | PLLA (core)/PLGA (shell) | PLLA (core)/PLGA (shell) | | Polymer concentration | PLLA (5%)/PLGA (5%) | PLLA (5%)/PLGA (5%) | PLLA (5%)/PLGA (5%) | PLLA (5%)/PLGA (5%) | PLLA (5%)/PLGA (5%) | PLLA (5%)/PLGA (5%) | | Growth factor type | BMP-2 (core)/VEGF (shell) | BMP-2 (core)/blank (shell) | Blank (core)/VEGF (shell) | BMP-2, VEGF (core)/BMP-2, VEGF (shell) | VEGF (core)/BMP-2 (shell) | Blank (core)/blank (shell) | | Growth factor solution | BMP-2 (100 μg/ml)/VEGF (10 μg/ml) | BMP-2 (100 μg/ml)/blank (shell) | Blank (core)/VEGF (10 μg/m) | BMP-2 (100 μg/ml), VEGF (10 μg/ml)/BMP-2 (100 μg/ml), VEGF (10 μg/ml) | VEGF (10 μg/ml)/BMP-2 (100 μg/ml) | Blank (core)/blank (shell) |
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