Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice
Table 1
Experimental design and drug treatment timeline.
Groups
Designations
Treatment received (days 1-9)
Treatment received (day 10 only)
Group 1
Control
0.9% saline/day (po)
0.9% saline/day (I.P)
Group 2
MTX
0.9% saline/day (po)
20 mg/kg MTX (I.P.)
Group 3
Omega-3
100 mg/kg bw/day omega-3 (po)
20 mg/kg MTX (I.P.)
Group 4
Omega-3
200 mg/kg bw/day omega-3 (po)
20 mg/kg MTX (I.P.)
Group 5
Vitamin C
100 mg/kg bw/day vitamin C (po)
20 mg/kg MTX (I.P.)
Group 6
Vitamin C
200 mg/kg bw/day vitamin C (po)
20 mg/kg MTX (I.P.)
Group 7
Combination
Omega-3 (100 mg/kg bw/day) and vitamin C (100 mg/kg bw/day) (po)
