Research Article
Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice
Table 2
Assessment of acute liver injury according to ranking tissue lesion severity from 0 to 3.
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No histopathological changes score (0), very mild histopathological changes in <5% of fields score (+/-), mild histopathological changes in <20% of fields score (+), moderate histopathological changes in 20 to 60% of fields score (++), and severe histopathological changes in >60% of fields score (+++). GR. A = control group; GR. B = MTX-injected group; GR. C and D = omega-3 pretreatment group in graded doses (100 mg and 200 mg); GR. E and F = vitamin C pretreatment group in graded doses (100 mg and 200 mg); GR. G = concomitant pretreated group with omega-3 (100 mg/kg) and vitamin C (100 mg/kg) for 10 days (each group contain 7 mice). |