Antifungal Activities of Phytochemically Characterized Hydroethanolic Extracts of Sclerocarya birrea Leaves and Stem Bark against Fluconazole-Resistant Candida albicans Strains

Table 2

Effect of S. birrea leaf and stem bark extracts in combination with fluconazole, nystatin, or caspofungin against C. albicans strains.

Strains

Combinations

SBL

SBB

FLC

NYS

CSF

FLC

NYS

CSF

FICI

INT

FICI

INT

FICI

INT

FICI

INT

FICI

INT

FICI

INT

ATCC 90028

0.50

S

0.5

S

0.28

S

1.50

I

0.38

S

0.63

I

ATCC 10231

0.31

S

0.38

S

0.75

I

1.50

I

0.28

S

0.38

S

SC5314

2.00

I

1.00

I

1.13

I

1.50

I

0.28

S

2.13

I

CA-R1

2.00

I

2.00

I

0.75

I

2.00

I

1.25

I

2.13

I

CA-R2

0.31

S

1.50

I

4.25

A

2.00

I

1.25

I

4.06

A

CA-R3

0.75

I

1.25

I

2.00

I

2.00

I

0.50

S

2.13

I

CA-R4

0.75

I

0.02

S

3.00

I

1.50

I

0.5

S

4.06

A

CA-R5

0.02

S

0.02

S

1.50

I

1.50

I

0.5

S

2.13

I

FLC: fluconazole; NYS: nystatin; CSF: caspofungin. FICI: Fraction Inhibitory Concentration Index; S: synergism for ; I: indifference FICI was >0.5 to ≤4.0; A: antagonism FICI >4.0 ().