Development and Validation of a Novel Circadian Rhythm-Related Signature to Predict the Prognosis of the Patients with Hepatocellular Carcinoma

<div>Expression of the circadian rhythm-related genes (CRGs) and their interactions. (a) Heatmap (green: low expression level; red: high expression level) of the CRGs between the normal (N, brilliant blue) and the tumor tissues (T, red). (b) Protein-protein interaction (PPI) network showing the interactions of the CRGs. (c) Calculation of the hub genes in PPI based on CytoHubba plug-in. (d) The correlation network of the CRGs (red line: positive correlation; blue line: negative correlation. The depth of the colors reflects the strength of the relevance).</div>

BioMed Research International

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Figure 2

Figure 2: Development and Validation of a Novel Circadian Rhythm-Related Signature to Predict the Prognosis of the Patients with Hepatocellular Carcinoma 

Figure 2 | Development and Validation of a Novel Circadian Rhythm-Related Signature to Predict the Prognosis of the Patients with Hepatocellular Carcinoma 