Development and Validation of a Novel Circadian Rhythm-Related Signature to Predict the Prognosis of the Patients with Hepatocellular Carcinoma

Figure 4

Constructing risk characteristics in TCGA cohort. (a) Univariate Cox regression analysis of OS for each DESs with for 10 genes. (b) LASSO regression of 10 OS-associated genes. (c) Cross-validation adjusted parameter selection for LASSO regression. (d) Patient distribution based on the risk score. (e) Survival status of each patient (low-risk population: left side of the dashed line; high-risk population: right side of the dashed line). (f) PCA and t-SNE plot for HCC based on the risk score. (g) Kaplan–Meier curve groups for OS in the high- and low-risk patients. (h) The ROC curves show the predictive efficiency of the risk score.

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