Evaluation of Zuo-Gui Yin Decoction Effects on Six CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

Figure 2

UPLC-MS/MS chromatogram of six probe drugs and the internal standard in rat plasma. (a) Blank plasma chromatogram. (b) Chromatogram of probe substrate standard plus internal standard solution. (c) Chromatogram of blank plasma plus probe substrate standard and glibenclamide standard. (d) Probe substrate and internal standard chromatogram after injection of probe substrate reference substance into rat tail vein. 1: phenacetin, 2: bupropion, 3: amodiaquine, 4: omeprazole, 5: dextromethorphan, 6: midazolam, and 7: glibenclamide.