Research Article
Evaluation of Zuo-Gui Yin Decoction Effects on Six CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS
Table 4
The method validation of six probe drugs in rat plasma sample.
| Compounds | RSD (%) of probe drugs | Lower limit | Interday precision | Intraday precision | Accuracy | Matrix effect | LQC | MQC | HQC |
| Phenacetin | 4.92 | 5.73 | 10.11 | 5.64 | 6.73 | 2.40 | 1.17 | 4.83 | 8.83 | 9.26 | 2.22 | 4.17 | 2.50 | 3.45 | 2.99 | 0.70 |
| Bupropion | 5.60 | 2.62 | 4.68 | 4.42 | 4.33 | 1.91 | 4.50 | 5.75 | 1.11 | 3.22 | 4.53 | 6.32 | 3.06 | 3.00 | 2.32 | 2.05 |
| Amodiaquine | 8.88 | 11.80 | 9.45 | 2.14 | 4.73 | 1.94 | 2.85 | 4.97 | 5.23 | 5.10 | 5.44 | 8.59 | 4.49 | 4.38 | 2.63 | 1.51 |
| Omeprazole | 5.60 | 6.05 | 8.11 | 5.00 | 3.02 | 0.95 | 2.46 | 8.36 | 1.62 | 3.57 | 4.20 | 1.73 | 2.74 | 2.49 | 5.97 | 1.40 |
| Dextromethorphan | 4.43 | 14.43 | 7.14 | 13.61 | 4.15 | 7.41 | 2.31 | 12.51 | 9.78 | 7.46 | 3.01 | 7.13 | 5.30 | 2.74 | 2.55 | 1.30 |
| Midazolam | 11.49 | 7.83 | 10.36 | 9.31 | 4.88 | 3.81 | 3.64 | 9.83 | 11.47 | 10.51 | 2.53 | 1.15 | 1.79 | 4.01 | 3.60 | 1.08 |
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