Evaluation of Zuo-Gui Yin Decoction Effects on Six CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

Table 5

(a) Main pharmacokinetic parameters of phenacetin in rat plasma (, )

Parameter	CG	LG	MG	HG
AUC(0-t) (ng/mL·min)
AUC(0-∞) (ng/mL·min)
MRT(0-∞) (min)
T1/2 (min)
CL (L/min/kg)

(b) Main pharmacokinetic parameters of bupropion in rat plasma (, )

Parameter	CG	LG	MG	HG
AUC(0-t) (ng/mL·min)
AUC(0-∞) (ng/mL·min)
MRT(0-∞) (min)
T1/2 (min)
CL (L/min/kg)

(c) Main pharmacokinetic parameters of amodiaquine in rat plasma (, )

Parameter	CG	LG	MG	HG
AUC(0-t) (ng/mL·min)
AUC(0-∞) (ng/mL·min)
MRT(0-∞) (min)
T1/2 (min)
CL (L/min/kg)

(d) Main pharmacokinetic parameters of omeprazole in rat plasma (, )

Parameter	CG	LG	MG	HG
AUC(0-t) (ng/mL·min)
AUC(0-∞) (ng/mL·min)
MRT(0-∞) (min)
T1/2 (min)
CL (L/min/kg)

Compared to CG, and .

(e) Main pharmacokinetic parameters of dextromethorphan in rat plasma (, )

Parameter	CG	LG	MG	HG
AUC(0-t) (ng/mL·min)
AUC(0-∞) (ng/mL·min)
MRT(0-∞) (min)
T1/2 (min)
CL (L/min/kg)

Compared to CG, and .

(f) Main pharmacokinetic parameters of midazolam in rat plasma (, )

Parameter	CG	LG	MG	HG
AUC(0-t) (ng/mL·min)
AUC(0-∞) (ng/mL·min)
MRT(0-∞) (min)
T1/2 (min)
CL (L/min/kg)

Compared to CG, and .