Network Pharmacology-Based Strategy for Predicting Therapy Targets of Citri Reticulatae Pericarpium on Myocardial Hypertrophy

Figure 6

Effect of naringenin on the expression of essential target genes (AKT, PPARA, PPARG, ESR1, and ERK1/2). H9C2 cells were treated with 20 μM naringenin for 1 h followed by stimulation with Ang II for 24 h. The mRNA expression of PPARA (a), PPARG (b), and ESR1 (c) were detected by real-time PCR. (d–f) The protein expression of ERK and AKT were checked by Western blotting. vs. the group without treatment, ^# vs. the group treated with Ang II, .

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