The High Expression of Minichromosome Maintenance Complex Component 5 Is an Adverse Prognostic Factor in Lung Adenocarcinoma

Table 2

Univariate and multivariate analysis of the correlation of MCM5 expression with OS in lung cancer patients.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage	996
T1	282	Reference
T2	557	1.375 (1.073-1.764)	0.012	1.216 (0.900-1.642)	0.203
T3 and T4	157	2.360 (1.742-3.197)	<0.001	1.831 (1.149-2.919)	0.011
N stage	981
N0	641	Reference
N1	222	1.527 (1.212-1.922)	<0.001	1.144 (0.761-1.722)	0.518
N2 and N3	118	2.018 (1.522-2.675)	<0.001	2.025 (1.119-3.666)	0.020
M stage	774
M0	742	Reference
M1	32	2.250 (1.427-3.548)	<0.001	2.063 (1.128-3.771)	0.019
Age	983
< =65	427	Reference
>65	556	1.259 (1.027-1.544)	0.027	1.368 (1.083-1.730)	0.009
Pathologic stage	987
Stage I	512	Reference
Stage II	278	1.605 (1.264-2.038)	<0.001	1.187 (0.769-1.833)	0.439
Stage III	164	2.239 (1.730-2.898)	<0.001	0.989 (0.513-1.908)	0.975
Stage IV	33	3.076 (1.947-4.859)	<0.001
MCM5	999
Low	501	Reference
High	498	1.274 (1.045-1.554)	0.017	1.216 (0.968-1.526)	0.093