Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

Table 3

Mean values (±S.E.M.) for all cytokines and receptors and the arithmetic difference between the mean values of patients and control subjects, in order of the magnitude of the change.

	Patients	Controls	Mean difference	X change	Mann–Whitney test
	()	()	Patients minus controls	Patients/controls	value
IL-1α			-0.67	0.48	0.0001
CCL27			-55.303	0.56	0.0001
CXCL12			9.563	1.26	0.38318
CXCL1			13.585	1.26	0.66127
CCL7			10. 394	1.56	0.02323
IL-8			25.123	1.66	0.00011
IL-16			92.703	1.76	0.04059
TNFβ			1.035	1.87	0.23723
SCF			38.464	2.14	0.00066
IFN-α2			12.616	2.41	0.00012
TRAIL			27.156	2.66	0.00002
IL-3			134.541	3.02	0.00015
IFN-γ			68.238	3.09	0.0001
IL-18			18.78	3.18	0.0001
IL- 12p40			200.548	3.28	0.0001
MIF			372.897	3.57	0.0001
LIF			6.335	3.64	0.00004
M-CSF			4.318	3.90	0.0001
G-CSF			24.925	4.09	0.0001
HGF			304.982	4.14	0.0001
IL-1 ra			110.147	4.50	0.0001
IL-2ra			105.065	4.64	0.0001
SCGF - b			6921.838	5.42	0.0001
CCL11			74.21	5.79	0.0001
CCL2			76.34	6.85	0.0001
IL-7			12.44	6.98	0.0001
IL-5			7.043	7.88	0.0001
GM-CSF			20.67	9.01	0.0001
IL-15			48.196	9.92	0.0001
IL-12(p70)			35	10.38	0.0001
TNF-α			39.495	14.48	0.0001
VEGF			160.402	11.59	0.0001
β-NGF			7.809	11.67	0.0001
IL-6			36.516	13.58	0.0001
CXCL9			1672.868	14.47	0.0001
FGF b			18.233	15.10	0.0001
IL-2			27.357	16.33	0.0001
IL-10			55.361	16.55	0.0001
IL-4			17.906	17 16	0.0001
IL-17			40.376	18.76	0.0001
IL-1β			15.007	19.60	0.0001
IL-9			92.698	27.47	0.0001
IL-13			35.588	27.60	0.0001
CCL3			46.857	49.31	0.0001
CCL5			3001.024	50.21	0.0001
PDGF-bb			7961.073	56.07	0.0001
CXCL10			3447.989	71.29	0.0001
CCL4			1010.289	99.37	0.0001

: numbers of control subjects in this case is 56. Mean difference: the arithmetic difference between the mean level of each cytokine in patients and controls (patient value minus control value). Numbers in italic are negative values indicating that the level of the cytokine was higher in controls relative to patients. Those in black show cytokine levels higher in patients compared to controls. X change: the ratio of the mean value in patients and that in controls (patient value divided by the control value). Here, numbers in italic have values less than 1, indicating that the level of the cytokine in each case was lower in patients than in controls. Numbers in bold show cytokine to 5 times higher in patients relative to controls. Numbers in black show cytokine to 10 times higher in patients relative to controls and those in bold italic show cytokine times higher in patients relative to controls. Significantly different cytokines between NE and controls, , Mann–Whitney test .