The Changes in Optic Nerve after Orbital Decompression Surgery for Thyroid Eye Disease and Case Reports of Ischemic Optic Neuropathy
Table 3
The univariable analysis of factors associated with RNFL deterioration after decompression.
Non-DON
DON
β-Coefficients (95% CI)
value
β-Coefficients (95% CI)
value
Age (years)
-0.15 (-0.29–-0.01)
0.035
-0.04 (-0.57–0.50)
0.898
Male sex
-1.68 (-4.75–1.40)
0.285
6.57 (0.71–12.40)
0.028
Intraocular pressure (mmHg)
0.04 (-0.13–0.20)
0.646
0.22 (-0.54–0.98)
0.563
LogMAR visual acuity
-13.0 (-23.00–-3.04)
0.011
-3.22 (-11.60–5.13)
0.450
Mean deviation (dB)
0.58 (0.29–0.87)
<0.001
-0.01 (-0.72–0.71)
0.989
Average RNFL (μm)
-0.09 (-0.24–0.06)
0.222
-0.58 (-0.87–-0.29)
<0.001
RNFL of superior quadrant (μm)
-0.02 (-0.09–0.05)
0.506
-0.17 (-0.31–0.03)
0.014
RNFL of temporal quadrant (μm)
-0.05 (-0.12–0.02)
0.168
-0.27 (-0.67–0.13)
0.186
RNFL of inferior quadrant (μm)
-0.03 (-0.11–0.05)
0.474
-0.18 (-0.38–0.03)
0.089
RNFL of nasal quadrant (μm)
-0.07 (-0.16–0.03)
0.167
-0.51 (-0.77–-0.25)
<0.001
Hertel exophthalmometry (mm)
0.05 (-0.48–0.59)
0.855
4.82 (2.28–7.36)
<0.001
BROD
-2.48 (-4.79–-0.18)
0.035
-7.95 (-15.40–-0.54)
0.036
Diplopia
1.36 (-1.41–4.13)
0.336
4.90 (-5.30–15.10)
0.347
EOM enlargement
-0.93 (-3.36–1.50)
0.453
Not available
Not available
Clinical activity score
0.20 (-0.78–1.17)
0.690
4.35 (2.85–5.85)
<0.001
Systemic steroid treatment
-2.12 (-4.78–0.53)
0.117
10.3 (3.61–17.00)
<0.001
BROD: bone removal orbital decompression; DON: dysthyroid optic neuropathy; LogMAR: logarithm of the minimum angle of resolution. The value of change in RNFL equals the postoperative average RNFL thickness minus the preoperative average RNFL thickness. The results are not available since all patients in the DON group had EOM enlargement. Significant values are shown in bold.
