Exploring the Prognosis of Breast Cancer with Synchronous Distant Nonregional Lymph Node Metastasis and Establishing a Predictive Model: A Population-Based Study
Table 3
Univariate and multivariate analyses for OS and BCSS of breast cancer patients with SDLNM.
Variables
OS
BCSS
Univariate
Multivariate
Univariate
Multivariate
Hazard ratio (95% CI)
Hazard ratio (95% CI)
Age
0.31
0.836
Marriage
0.046
1.27 (0.91, 1.78)
0.156
0.132
Race
0.025
0.023
White
Reference
Reference
Black/AI
1.24 (0.84, 1.84)
0.283
1.42 (0.93, 2.17)
0.100
Asian
0.59 (0.28, 1.23)
0.160
0.37 (0.32, 1.44)
0.310
Histology
0.24
0.557
SBR grade
<0.001
<0.001
Grade 3
Reference
Reference
Grade 1-2
0.58 (0.37, 0.91)
0.016
0.52 (0.31, 0.86)
0.011
Unknown
0.69 (0.45, 1.05)
0.082
0.72 (0.45, 1.16)
0.180
T stage
0.013
0.094
T4
Reference
Reference
T3
0.65 (0.39, 1.10)
0.106
0.64 (0.38, 1.08)
0.097
T2
0.56 (0.37, 0.84)
0.005
0.62 (0.38, 0.98)
0.043
T0-1
0.41 (0.24, 0.69)
<0.001
0.53 (0.30, 0.95)
0.032
N stage
0.118
0.098
N3
Reference
N2
0.64 (0.38, 1.08)
0.057
N1
0.62 (0.38, 0.99)
0.580
N0
0.53 (0.30, 0.95)
0.530
Subtype
<0.001
<0.001
Luminal A
Reference
Reference
Luminal B
0.49 (0.29, 0.87)
0.014
0.43 (0.23, 0.80)
0.007
Her2 + HR-
0.56 (0.30, 1.04)
0.064
0.49 (0.25, 0.94)
0.032
TNBC
2.21 (1.49, 3.28)
<0.001
2.07 (1.31, 3.27)
0.002
Surgery
0.001
0.004
None
Reference
Reference
Lumpectomy
0.85 (0.49, 1.47)
0.555
1.01 (0.58, 1.77)
0.960
Mastectomy
0.63 (0.41, 0.95)
0.026
0.79 (0.50, 1.25)
0.310
Radiotherapy
<0.001
1.61 (1.07, 2.44)
0.024
<0.001
1.83 (1.19, 2.84)
0.006
Chemotherapy
0.171
0.848
BCSS: breast cancer-specific survival; CI: confidence intervals; Her2: human epidermal growth factor receptor type 2; HR: hormone receptor; OS: overall survival; SBR grade: Scarff-Bloom-Richardson grading system; SDLNM: synchronous isolated distant lymph node metastasis; TNBC: triple-negative breast cancer.
