Hematological Inflammatory Markers in Patients with Clinically Confirmed Familial Hypercholesterolemia
Table 3
Comparison of crude and adjusted inflammatory markers between FH and non-FH participants.
Parameter
Comparing non-FH, possible, and definite and probable group
Comparing FH and non-FH
β (95% CI)
value
β (95% CI)
value
NLr
Model 1
0.05 (-0.025, 0.125)
0.195
0.07 (-0.04, 0.18)
0.196
Model 2
0.05 (-0.034, 0.128)
0.253
0.06 (-0.06, 0.17)
0.337
Model 3
-0.02 (-0.091, 0.052)
0.596
-0.05 (-0.15, 0.05)
0.377
Model 4
-0.01 (-0.09, 0.08)
0.902
-0.03 (-0.14, 0.08)
0.551
PLr
Model 1
0.21 (0.105, 0.311)
<0.001
0.23 (0.08, 0.38)
0.003
Model 2
0.18 (0.069, 0.299)
0.002
0.19 (0.02, 0.36)
0.026
Model 3
0.07 (0.018, 0.118)
0.007
0.08 (0.01, 0.15)
0.032
Model 4
0.06 (0.01, 0.12)
0.029
0.07 (-0.01, 0.14)
0.013
RPr
Model 1
-0.001 (-0.002, 0.001)
0.302
-0.001 (-0.003, 0.001)
0.212
Model 2
-0.001 (-0.002, 0.0001)
0.096
-0.002 (-0.004, 0.000)
0.052
Model 3
0.001 (-0.001, 0.002)
0.478
0.0001 (-0.002, 0.002)
0.948
Model 4
0.002 (-0.0002, 0.004)
0.079
0.001 (-0.001, 0.004)
0.431
WBC103
Model 1
-0.17 (-0.44, 0.10)
0.216
-0.26 (-0.67, 0.14)
0.196
Model 2
-0.14 (-0.44, 0.16)
0.353
-0.26 (-0.70, 0.18)
0.252
Model 3
-0.34 (-0.93, 0.25)
0.259
-0.45 (-1.29, 0.39)
0.291
Model 4
-0.27 (-0.95, 0.41)
0.431
-0.36 (-1.26, 0.54)
0.437
PDW
Model 1
0.08 (-0.06, 0.23)
0.263
0.18 (-0.03, 0.39)
0.085
Model 2
0.05 (-0.09, 0.20)
0.492
0.12 (-0.10, 0.34)
0.291
Model 3
0.01 (-0.23, 0.25)
0.940
0.04 (-0.29, 0.38)
0.808
Model 4
0.01 (-0.27, 0.28)
0.962
0.05 (-0.32, 0.41)
0.807
Model 1: crude effect; Model 2: adjust for age, BMI, and smoking statues; Model 3: additionally, adjusted for antilipid drug, aspirin consumption, history of CVD, and history of diabetes; Model 4: additionally, adjusted for total cholesterol. Data are shown as β (95% CI). Linear random intercept model was used.
