A Novel Missense <i>WFS1</i> Variant: Expanding the Mutational Spectrum Associated with Nonsyndromic Low-Frequency Sensorineural Hearing Loss

<div>Subcellular localization of wild-type (WT) and mutated WFS1. Immunofluorescence staining was performed after transient transfection in HEK-293 cells and HEI-OC1 cells. Images display DAPI in blue, endoplasmic reticulum-specific marker Calnexin in green, Flag-tagged protein in red, and merged pictures. In both HEK-293 cells and HEI-OC1 cells, the variant protein was located in the cytoplasmic endoplasmic reticulum as in the WT. Scale bars =30 <i>μ</i>m.</div>

BioMed Research International

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Figure 5

Figure 5: A Novel Missense <i>WFS1</i> Variant: Expanding the Mutational Spectrum Associated with Nonsyndromic Low-Frequency Sensorineural Hearing Loss 

BioMed Research International

A Novel Missense WFS1 Variant: Expanding the Mutational Spectrum Associated with Nonsyndromic Low-Frequency Sensorineural Hearing Loss

Figure 5